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Arthritis as a Manifestation of Systemic Disease Follow-up

  • Author: Ritu Khurana, MD; Chief Editor: Herbert S Diamond, MD  more...
Updated: Nov 10, 2014


In general, therapy to manage the underlying illness results in improvement or complete resolution of the joint manifestations. Acute sarcoid arthritis does not cause joint damage.

In contrast, most patients with acromegaly have had the disease for many years prior to diagnosis and are left with cartilage hypertrophy and severe degenerative joint disease. The arthritis of hemochromatosis does not improve with phlebotomy.


Patient Education

For patient education resources, see the Arthritis Center and Muscle Disorders Center, as well as Knee Pain.

Contributor Information and Disclosures

Ritu Khurana, MD Chief of Rheumatology, Crozer Chester Medical Center, Upland, PA

Ritu Khurana, MD is a member of the following medical societies: American College of Physicians, American College of Rheumatology, International Society for Clinical Densitometry

Disclosure: Nothing to disclose.

Specialty Editor Board

Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Received salary from Medscape for employment. for: Medscape.

Lawrence H Brent, MD Associate Professor of Medicine, Jefferson Medical College of Thomas Jefferson University; Chair, Program Director, Department of Medicine, Division of Rheumatology, Albert Einstein Medical Center

Lawrence H Brent, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Physicians, American College of Rheumatology

Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Janssen<br/>Serve(d) as a speaker or a member of a speakers bureau for: Abbvie; Genentech; Pfizer; Questcor.

Chief Editor

Herbert S Diamond, MD Visiting Professor of Medicine, Division of Rheumatology, State University of New York Downstate Medical Center; Chairman Emeritus, Department of Internal Medicine, Western Pennsylvania Hospital

Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, Phi Beta Kappa

Disclosure: Nothing to disclose.

Additional Contributors

Kristine M Lohr, MD, MS Professor, Department of Internal Medicine, Interim Chief, Division of Rheumatology, Director, Rheumatology Training Program, University of Kentucky College of Medicine

Kristine M Lohr, MD, MS is a member of the following medical societies: American College of Physicians, American College of Rheumatology

Disclosure: Nothing to disclose.


The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors R Hal Scofield, MD and Linda A Zacharias, MD to the development and writing of this article.

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This picture shows a 42-year-old white man who was admitted with acute back pain. In this frontal view, note the lower-face fullness that obscures his ears and the plethora of his cheeks.
Focal osteolytic changes seen in the phalanges in a patient with chronic sarcoid arthritis.
Osteolysis has left a lacy trabecular pattern in this phalanx (arrow).
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