Carboplatin AUC Dose Calculation (Calvert formula)

Input:
Target AUC  
Sex Male (1)

Female (0.85)
Age
Serum Creat
Weight
Results:
GFR
Carboplatin Dose
 
Decimal Precision:
GFR = Sex * ((140 - Age) / (SerumCreat)) * (Weight / 72)
CarboplatinDose = TargetAUC * (GFR + 25)
  • Equation parameters such as Sex have two or more discrete values that may be used in the calculation. The numbers in the parentheses, e.g. (1), represent the values that will be used.
  • The default unit of measure for weight is kilograms. Please verify that the correct unit of measure has been selected.
  • Target AUC represents the desired area under the concentration times time curve.
  • Because renal function may change through a course of chemotherapy, this calculation should be repeated prior to each dose of carboplatin.
  • Target AUC typically ranges between 5 and 7.
  • This calculator estimates GFR from the Cockcroft-Gault equation.
  • Total Carboplatin Dose is calculated in mg and NOT mg/m2.
  1. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
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