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Hyponatremia Correction Infusate Rate

Input:
Serum Na Change Per Hr
Serum Na
Water Fract Child (0.6)

Adult Male (0.6)

Adult Female (0.5)

Elderly Male (0.5)

Elderly Female (0.45)
Weight
IV Na 5% NaCl (855)

3% NaCl (513)

0.9% NaCl (Normal Saline) (154)

Ringer Lactate (Includes 4 mEq/L K+) (134)
IV K
Results:
Infusate Rate
Serum Na Change Per Liter
 
Decimal Precision:
InfusateRate = (1000 * SerumNaChangePerHr * ((WaterFract * Weight) + 1)) / (IVNa + IVK - SerumNa)
SerumNaChangePerLiter = (IVNa + IVK - SerumNa) / ((WaterFract * Weight) + 1)
  • The default unit of measure for weight is kilograms. Please verify that the correct unit of measure has been selected.
  • OVERLY RAPID CORRECTION OF HYPONATREMIA MAY CAUSE CEREBRAL EDEMA AND OSMOTIC DEMYELINATION WHICH CAN RESULT IN BRAIN DAMAGE OR DEATH.
  • The serum Sodium should generally be corrected at a rate that does not exceed 8 mEq/L/day. Remaining within this target, the initial rate of correction can still be 1-2 mEq/L/hr for several hours in patients with severe symptoms.
  • In milder cases, fluid restriction alone (800-1200 mL/day) is usually adequate to correct the serum sodium.
  • Hypokalemia can aggravate the cerebral effects of hyponatremia and should be corrected.
  • Equation parameters such as Water Fract have two or more discrete values that may be used in the calculation. The numbers in the parentheses, e.g. (0.6), represent the values that will be used.
  1. Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342(21):1581-89.
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