acamprosate (Rx)

Brand and Other Names:Campral
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 333mg
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Alcholism

Indicated for maintenance of alcohol abstinence in patients who are abstinent at treatment initiation

666 mg PO TID

Renal Impairment

CrCl 30-50 mL/min: 333 mg PO TID

CrCl <30 mL/min: Do not administer

Fragile X Syndrome (Orphan)

Orphan designation for treatment of fragile X syndrome

Orphan sponsor

  • Confluence Pharmaceuticals, LLC; Box 528, 351 West 10th Street; Indianapolis, IN 46202

Safety and efficacy have not been established

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Interactions

Interaction Checker

and acamprosate

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Diarrhea (16%)

            1-10%

            Accidental injury (3%)

            Anorexia (3%)

            Anxiety (6%)

            Asthenia (6%)

            Depression (5%)

            Dizziness (3%)

            Dry mouth (2%)

            Flatulence (3%)

            Insomnia (7%)

            Nausea (4%)

            Pain (3%)

            Paresthesia (2%)

            Pruritus (4%)

            Sweating (2%)

            Frequency Not Defined

            Hypertension

            Chest-pain

            Edema

            Syncope

            Vasodilation

            Abnormal vision

            Cough

            Pharyngitis

            Dyspnea

            Rhinitis

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            Warnings

            Contraindications

            Hypersensitivity

            Severe renal impairment

            Cautions

            Does not diminish withdrawal symptoms

            May impair ability to operate heavy machinery or drive

            Efficacy not established in promoting abstinence in non-abstinent patients

            Check for suicidal tendencies

            Use as part of a conprehensive to treat alcohol dependence

            Possibility of acute renal failure (ARF)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Not fully understood; may act by interacting with glutamate & GABA neurotransmitter systems

            Does not cause alcohol aversion or a disulfiram-like reaction on ethanol ingestion

            Pharmacokinetics

            Protein Bound: Negligible

            Vd: 1 L/kg

            Peak PlasmaTime: 3-8 hr

            Concentration: 350 ng/mL for a dose of 666 mg TID

            Bioavailability: 11%, decreased by food

            Metabolism: None

            Excretion: Urine

            Half-life: 20-33 hr

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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