0.6-3 g dried root PO qDay
400 mg standardized extract PO qDay/TID
Therapy for 30-60 days, followed by 2-3 weeks off
Extract standardized to 0.3% eleutheroside E
Adaptogen: adapt to internal/external stressors, fight fatigue, increase stamina
Reduce severity/duration of herpes simplex type II infections
Arterosclerosis, athletic/work performance enhancement, chronic fatigue syndrome, craniocerebral trauma, diabetes, fibromyalgia, hypertension/hypotension, immunostimulant, neuroses
Possibly effective for common cold and herpes simplex virus type 2
Possibly ineffective for athletic performance
Insufficient reliable evidence on chronic fatigue syndrome, cognitive performance, heart disease, influenza, ischemic stroke and quality of life
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Breast cancer, endometrial cancer, endometriosis, febrile conditions, hormone sensitive conditions, hypertension, ovarian cancer, uterine fibroids
CAD, cardiovascular disorders, mania, MI, psychiatric disorders, rheumatic heart disease, schizophrenia
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Eleuthorosides A through M modulate pituitary-adrenocortical axis
Antioxidant and immunostimulant activity