Dried root: 300-2000 mg PO TID
Extract: 0.3-2 mL PO daily; 1:1, 90% alcohol
Tincture: 2-4 mL PO daily; 1:10, 60% alcohol
Tablet: 20-80 mg PO BID; standardized to 1 mg triterpene glycosides/20 mg tablet
Cough/sore throat, dysmenorrhea, dyspepsia, labor induction, menopausal symptoms, nervous tension, premenstrual syndrome, rheumatism
Likely effective for menopausal vasomotor symptoms
Possibly effective for PMS/dysmenorrhea
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Breast cancer, endometrial cancer, endometriosis, hormone sensitive conditions, ovarian cancer, pregnancy, lactation, uterine fibroids
May be associated with liver damage
Pregnancy & Lactation
Pregnancy Category: unsafe
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
May act by blocking serotonin reuptake