chlorpheniramine/phenylephrine (OTC)

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Brand and Other Names:Actifed Cold and Allergy

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

chlorpheniramine/phenylephrine

tablet

  • 4mg/10mg
more...

Nasal Congestion or Sneezing Due to Common Cold, Hay Fever, Allergic Rhinitis

Actifed Cold and Allergy

  • 1 tablet PO q4hr; not to exceed 6 tab/24h

Sudafed PE Sinus & Allergy

  • 1 tablet PO q4hr not to exceed 6 tablets/24hr

Dosage Forms & Strengths

chlorpheniramine/phenylephrine

tablet

  • 4mg/10mg
more...

Nasal Congestion or Sneezing Due to Common Cold, Hay Fever, Allergic Rhinitis

Not recommended for children <12 yo

>12 Years Old

  • Actifed Cold and Allergy: 1 tablet PO q4hr; not to exceed 6 tab/24 hr
  • Sudafed PE Sinus & Allergy: 1 tablet PO q4hr; not to exceed 6 tablets/24 hr
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Interactions

Interaction Checker

and chlorpheniramine/phenylephrine

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Hypertension

            Hypotension

            Palpitations

            Reflex tachycardia

            Severe peripheral and visceral vasoconstriction

            Tachycardia

            Confusion

            Depression

            Distress

            Dizziness

            Excitability

            Euphoria

            Fatigue

            Headache

            Insomnia

            Irritability

            Restlessness

            Sedation

            Tremor

            Anorexia

            Agranulocytosis

            Hemolytic anemia

            Thrombocytopenia

            Thickening of bronchial secretions

            Wheezing

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            Warnings

            Contraindications

            Contraindicated in documented hypersensitivity; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer

            Cautions

            Caution in elderly patients, hyperthyroidism, myocardial disease, bradycardia, partial heart block or severe arteriosclerosis when administering phenylephrine; in hypovolemia, phenylephrine use is not a substitute for replacement of blood, fluids and electrolytes, and plasma (promptly restore with loss); dilute IV and administer via large vein; extravasation precautions required

            Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown/contraindicated

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle.

            Phenylephrine is a vasoconstrictor and a decongestant that relieves symptoms resulting from irritation of upper respiratory tract tissue. It shrinks swollen mucous membranes, reduces nasal congestion and tissue hyperemia.

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            Images

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