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interferon gamma 1b (Rx)Brand and Other Names:Actimmune

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 100mcg/0.5mL (single-dose vial)
  • 50mcg = 1 million units/m²
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Chronic Granulomatous Disease

Indicated to reduce frequency and severity of infections associated with chronic granulomatous disease

BSA >0.5 m²: 50 mcg/m² SC 3 times/week 

BSA ≤0.5 m²: 1.5 mcg/kg SC 3 times/week

Malignant Osteopetrosis

Indicated to delay time to progression for severe malignant osteopetrosis

BSA >0.5 m²: 50 mcg/m² SC 3 times/week 

BSA ≤0.5 m²: 1.5 mcg/kg SC 3 times/week

Orphan Designations

Friedriech's ataxia

Renal cell carcinoma

Sponsor

  • Horizon Pharma Ireland Limited; Adelaide Chambers; Dublin 8; IRELAND

Administration

Optimum sites are right and left deltoid, anterior thigh

If severe reactions occur, reduce dose by 50 percent or discontinue therapy until the adverse reaction abates

Monitor

CBC, blood chemistries, urinalysis: q3month

Dosage Forms & Strengths

injectable solution

  • 100mcg/0.5mL (single-dose vial)
  • 50mcg = 1 million units/m²
more...

Chronic Granulomatous Disease

BSA >0.5 m²: 50 mcg/m² SC 3 times/week 

BSA <0.5 m²: 1.5 mcg/kg SC 3 times/week

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Interactions

Interaction Checker

interferon gamma 1b and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Fever (52%)

            Headache (33%)

            Rash (17%)

            Chills (14%)

            Diarrhea (14%)

            Injection site erythema/tenderness (14%)

            Vomiting (13%)

            Nausea (10%)

            1-10%

            Arthralgia

            Myalgia

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            Warnings

            Contraindications

            Hypersensitivity to interferon gamma or E. coli-derived products

            Cautions

            Immunocompromised patients

            Potential for hepatotoxicity

            If severe reactions occur, decrease dose 50% or withhold until side effects subside

            Caution in cardiovascular disease; pre-existing cardiac conditions may be exacerbated

            Reduce dose or discontinue if decreased mental status, gait disturbance, dizziness occur

            Monitor for neutropenia and thrombocytopenia particularly when administering in combination with other potentially myelosuppressive agents

            Reduce dose or discontinue to reverse severe elevations of aspartate transaminase (AST) and/or alanine transaminase (ALT); monitor liver function monthly in patients <1 year old

            If serious hypersensitivity reactions occur, discontinue and institute appropriate medical therapy

            Monitor renal function regularly when administering therapy to patients with severe renal insufficiency

            Refrigerate vials-do not freeze or shake

            The stopper of the glass vial contains natural rubber (a derivative of latex) which may cause allergic reactions

            May cause flu-like symptoms

            No preservatives-discard unused portions

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not known whether excreted in breast milk, discontinue drug or do not nurse

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Recombinant human interferon gamma-1b, cytokine that confers greater resistance to microbial pathogens and regulates immune processes

            Pharmacokinetics

            Absorption: 89% (SC, IM)

            Half-life: 38 min (IV); 3 hr (IM); 5.9 hr (SC)

            Peak plasma time: 4 hr (IM); 7 hr (SC)

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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