Same (Herbs/Suppl)

Brand and Other Names:ademetionine, adenosylmethionine, more...Adomet, Gumbaral, Heptral, Sadenosyl Lmethionine, sammy, Samyr
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Suggested Dosing

Depression

Oral: 400-1600 mg PO qDay

IM/IV: 200-400 mg/day

Osteoarthritis

Oral: 200 mg PO TID

IV: 400 mg/day IV

Liver Disease, Alcohol Related

Oral: 1200-1600 mg PO qDay; no more than 24 months

IV: 200-2000 mg/day IV x 15-30 days

IM: 200 mg/day IM x 30 days

Intrahepatic Cholestasis

Oral: 800 mg PO BID

Fibromyalgia

800 mg PO qDay

AIDS-related Myelopathy (Orphan)

800 mg/day IV x 14 days

Orphan indication sponsor

  • Genopia USA, Inc; 90 Gold Street, 6N; New York, NY 10038
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Suggested Uses

AIDS-related myelopathy, Alzheimer's disease, bursitis/tendinitis, depression, fibromyalgia, heart disease, intrahepatic cholestasis, liver disease, migraine headache, osteoarthritis

Efficacy

Several studies showed comparable effectiveness to TCAs

Standardization of product not as good in US as in Europe

Oral form has poor bioavailability; pos. studies used parenteral SAMe

Mult clinical trials showed comparable effectiveness to NSAIDS, with fewer side effects

Studies showed possibly effective for the treatment of AIDS-related myelopathy, fibromyalgia,& intrahepatic cholestasis

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Interactions

Interaction Checker

and Same

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Anxiety

            Diarrhea

            Flatulence

            Headache

            Hypomania/mania

            Nausea/vomiting

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            Warnings

            Contraindications

            MAO inhibitor use within 14 day

            Cautions

            Bipolar disorder

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            Pregnancy & Lactation

            Pregnancy Category: N/A

            Lactation: N/A

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Methyl donor in many metabolic reactions

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