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phentermine (Rx)Brand and Other Names:Adipex P

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule, HCl salt: Schedule IV

  • 15mg
  • 30mg
  • 37.5mg

tablet, HCl salt: Schedule IV

  • 37.5mg
more...

Obesity

Short-term (few weeks) adjunctive use as part of weight-reduction regimen based on exercise, behavioral modification, and caloric restriction in management of exogenous obesity for patients with initial body mass index (BMI) ≥30 kg/m² or ≥27 kg/m² in presence of other risk factors (eg, controlled hypertension, diabetes, hyperlipidemia)

15-37.5 mg/day PO in single daily dose or divided q12hr before breakfast or 1-2 hr after breakfast

Adjust dosing according to patient's needs to achieve adequate response with lowest effective dosage

Dosage Forms & Strengths

capsule, HCl salt: Schedule IV

  • 15mg
  • 30mg
  • 37.5mg

tablet, HCl salt: Schedule IV

  • 37.5mg
more...

Obesity

Short-term (few weeks) adjunctive use as part of weight-reduction regimen based on exercise, behavioral modification, and caloric restriction in management of exogenous obesity for patients with initial BMI ≥30 kg/m² or ≥27 kg/m² in presence of other risk factors (eg, controlled hypertension, diabetes, hyperlipidemia)

<16 years: Not recommended

≥16 years: 15-37.5 mg/day PO in single daily dose or divided q12hr before breakfast or 1-2 hr after breakfast

Adjust dosing according to patient's needs to achieve adequate response with lowest effective dosage

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Interactions

Interaction Checker

phentermine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Bad taste in mouth

            Blurred vision

            Changes in libido

            Chills

            Constipation

            Diarrhea

            Drug-induced GI disturbance

            Dry mouth

            Dysphoric mood

            Dysuria

            Excitement

            Hair loss

            Headache

            Hypertension

            Impotence

            Insomnia

            Myalgia

            Nausea

            Nervousness

            Palpitations

            Restlessness

            Tachycardia

            Tremor

            Urticaria

            Vomiting

            Serious

            • Heart valve disorder
            • Primary pulmonary hypertension
            • Psychotic disorder
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            Warnings

            Contraindications

            Known hypersensitivity or idiosyncratic reaction to sympathomimetic amines

            Arteriosclerosis, cardiovascular disease, moderate-to-severe hypertension, arrhythmias, stroke, congestive heart failure, coronary artery disease, glaucoma, agitation, hyperthyroidism

            History of drug abuse

            Use of monoamine oxidase inhibitors (MAOIs) within preceding 14 days; concomitant administration of other CNS stimulants

            Pregnancy and breast feeding

            Cautions

            Primary pulmonary hypertension and valvular disease have been reported with therapy

            Avoid use of stimulants in patients with serious heart rhythm disturbances, cardiac abnormalities, cardiomyopathies, or other cardiac problems

            Patients with diabetes mellitus should use caution with antidiabetic agents like insulin or other hypoglycemic agents; dietary restrictions may lower requirements for antidiabetic therapy

            Drug has not been studied in renal impairment

            Use with caution in patients with seizure disorders or Tourette syndrome

            May impair ability to operate heavy machinery

            Concomitant administration with other weight-loss agents (eg, selective serotonin reuptake inhibitors [SSRIs], herbal preparations, other over-the-counter products) has not been studied

            Elderly are at high risk for myocardial infarction, hypertension, angina, or becoming dependent on phentermine with prolonged use

            Discontinue if weight loss has not occurred with 4 weeks of therapy

            Not approved for long-term use

            Discontinue if tolerance develops, and do not exceed recommended dosage to overcome tolerance

            Suprenza 15 mg and 30 mg ODT contain FD&C Yellow No. 5 (tartrazine); associated with allergic-type reactions in susceptible individuals

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            Pregnancy & Lactation

            Pregnancy category: X

            Lactation: Unknown if excreted in milk; contraindicated

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Amphetamine-related anorexigenic agent; action in reducing appetite may be secondary to CNS effects that may involve stimulation of hypothalamus to release norepinephrine

            Absorption

            Peak plasma time: 3.0-4.4 hr (orally disintegrating tablet)

            Elimination

            Excretion: Urine (primarily)

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • View the formulary and any restrictions for each plan.
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            • Compare formulary status to other drugs in the same class.
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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Select a class to view formulary status for similar drugs

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