ibuprofen/chlorpheniramine/pseudoephedrine (OTC)

Brand and Other Names:Advil Allergy Sinus
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ibuprofen/chlorpheniramine/pseudoephedrine

caplet

  • 200mg/2mg/30mg
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Allergy & Cold Symptoms

1 caplet PO q4-6hr prn while symptoms persist

Not to exceed 6 caplets/24 hr

Administration

Take with food or milk if stomach upset occurs

Dosage Forms & Strengths

ibuprofen/chlorpheniramine/pseudoephedrine

caplet

  • 200mg/2mg/30mg
more...

Allergy & Cold Symptoms

<12 years: Safety and efficacy not established

12 years or older: 1 caplet PO q4-6hr prn while symptoms persist; not to exceed 6 caplets/24 hr

Administration

Take with food or milk if stomach upset occurs

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Interactions

Interaction Checker

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            Adverse Effects

            Frequency Not Defined

            Drowsiness

            GI upset

            Insomnia

            Urinary retention

            Xerostomia

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            Warnings

            Contraindications

            Hypersensitivity

            Do not use immediately before or after heart surgery

            Do not use with MAO inhibitors or for 2 weeks after discontinuing MAO inhibitors because of risk for hypertensive crisis

            Cautions

            Caution with hypertension, heart disease, hepatic or renal impairment, asthma, thyroid disease, diabetes, glaucoma, or BPH

            NSAID content

            • May increase risk for GI ulceration
            • Coadministration with antiplatelets/anticoagulants
            • May decrease benefit of cardioprotective low-dose aspirin

            Antihistamine content

            • Additive risk for sedation when coadministered with other sedatives or alcohol
            • Caution when driving or operating machinery
            • May cause urinary retention, blurred vision, or dry mouth

            Decongestant content

            • May exacerbate poorly controlled hypertension
            • Caution if underlying cardiovascular risks present
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            Pregnancy & Lactation

            Do not take NSAIDs within 3 months before delivery, NSAIDs are know to cause premature closure of the ductus arteriosus

            The Quebec Pregnancy Registry identified 4705 women who had spontaneous abortions by 20 weeks' gestation; each case was matched to 10 control subjects (n=47,050) who had not had spontaneous abortions; exposure to nonaspirin NSAIDs during pregnancy was documented in approximately 7.5% of cases of spontaneous abortions and in approximately 2.6% of controls. (CMAJ, September 6, 2011; DOI:10.1503/cmaj.110454)

            Lactation: NSAIDs and pseudoephedrine excreted in breast milk, AAP states compatible with breastfeeding

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Ibuprofen: Inhibits synthesis of prostaglandins by inhibiting cyclooxygenase (COX-1, COX-2)

            Chlorpheniramine: H1-receptor antagonist

            Pseudoephedrine: Sympathomimetic; alpha adrenergic agonist

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