ibuprofen/chlorpheniramine/pseudoephedrine (OTC)

Brand and Other Names:Advil Allergy Sinus
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ibuprofen/chlorpheniramine/pseudoephedrine

caplet

  • 200mg/2mg/30mg
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Allergy & Cold Symptoms

1 caplet PO q4-6hr prn while symptoms persist

Not to exceed 6 caplets/24 hr

Administration

Take with food or milk if stomach upset occurs

Dosage Forms & Strengths

ibuprofen/chlorpheniramine/pseudoephedrine

caplet

  • 200mg/2mg/30mg
more...

Allergy & Cold Symptoms

<12 years: Safety and efficacy not established

12 years or older: 1 caplet PO q4-6hr prn while symptoms persist; not to exceed 6 caplets/24 hr

Administration

Take with food or milk if stomach upset occurs

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Interactions

Interaction Checker

and ibuprofen/chlorpheniramine/pseudoephedrine

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            Adverse Effects

            Frequency Not Defined

            Drowsiness

            GI upset

            Insomnia

            Urinary retention

            Xerostomia

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            Warnings

            Contraindications

            Hypersensitivity

            Do not use immediately before or after heart surgery

            Do not use with MAO inhibitors or for 2 weeks after discontinuing MAO inhibitors because of risk for hypertensive crisis

            Cautions

            Caution with hypertension, heart disease, hepatic or renal impairment, asthma, thyroid disease, diabetes, glaucoma, or BPH

            NSAID content

            • May increase risk for GI ulceration
            • Use caution in coadministration with antiplatelets/anticoagulants
            • May decrease benefit of cardioprotective low-dose aspirin
            • NSAIDS, except aspirin, increase risk of heart attack, heart failure, and stroke; which can be fatal; the risk is higher if patients use more than it was directed or for longer than needed
            • Use caution in patients with high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, have trouble urinating due to an enlarged prostate gland, or had a stroke
            • Patients should inform healthcare professional if they have symptoms of heart problems or stroke, chest pain, trouble breathing, weakness in one part or side of body, slurred speech, leg swelling

            Antihistamine content

            • Additive risk for sedation when coadministered with other sedatives or alcohol
            • Caution when driving or operating machinery
            • May cause urinary retention, blurred vision, or dry mouth

            Decongestant content

            • May exacerbate poorly controlled hypertension
            • Caution if underlying cardiovascular risks present
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            Pregnancy & Lactation

            Do not take NSAIDs within 3 months before delivery, NSAIDs are know to cause premature closure of the ductus arteriosus

            The Quebec Pregnancy Registry identified 4705 women who had spontaneous abortions by 20 weeks' gestation; each case was matched to 10 control subjects (n=47,050) who had not had spontaneous abortions; exposure to nonaspirin NSAIDs during pregnancy was documented in approximately 7.5% of cases of spontaneous abortions and in approximately 2.6% of controls. (CMAJ, September 6, 2011; DOI:10.1503/cmaj.110454)

            Lactation: NSAIDs and pseudoephedrine excreted in breast milk, AAP states compatible with breastfeeding

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Ibuprofen: Inhibits synthesis of prostaglandins by inhibiting cyclooxygenase (COX-1, COX-2)

            Chlorpheniramine: H1-receptor antagonist

            Pseudoephedrine: Sympathomimetic; alpha adrenergic agonist

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