Follow manufacturer's protocol
Commercial products suggest doses ranging from 500 mg-4.5 grams given PO in 2-6 divided doses daily
Cancer prevention & treatment
Treatment of arthritis & psoriasis
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Vomiting or diarrhea
Pain or swelling in the upper right part of the abdomen
Yellowing of skin or white parts of eyes
Low blood pressure
May contain heavy metal contaminants such as mercury & cadmium
Do not take in high doses or for long periods of time
Pregnancy & Lactation
Pregnancy Category: do not use
Lactation: do not use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Inhibits angiogenesis & interferes with matrix metalloproteases (MMPs) enzymes