Horse Chestnut Seed (Herbs/Suppl)

Brand and Other Names:aescin, Aesculaforce, more...aesculus hippocastanum, chestnut, de marronier d'Inde, eschilo, escine, graine de marronier d'Inde, HCSE, hippocastani semen, marron europeen, marronier, rosskastanie, Spanish chestnut, venastat, venostat, venostatin, Venostasin
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Suggested Dosing

Seed Extract

250-750 mg/d PO in div doses

Tincture

1-4 ml PO TID

Other Information

Extract standardized to 20-22% saponins

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Suggested Uses

Diarrhea, fever, hemorrhoids, phlebitis, prostate enlargement, varicose veins, venous insufficiency

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Interactions

Interaction Checker

and Horse Chestnut Seed

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Anaphylaxis (IV)

            GI irritation

            Itching

            Kidney toxicity (IV)

            Liver toxicity (IV)

            Toxic nephropathy

            Depression

            Diarrhea

            Incoordination

            Muscle twitching

            Paralysis

            Pupil dilation

            Stupor

            Vomiting

            Weakness

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            Warnings

            Contraindications

            Hepatitic impairment, infectious GI conditions, inflammatory GI conditions, renal impairment

            Cautions

            Bleeding disorders, concurrent hypoglycemic agents, diabetes mellitus

            WARNING: use only standardized seed extract; raw seed, leaf, bark, or flower possibly fatal

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            Pregnancy & Lactation

            Pregnancy Category: raw seed unsafe; avoid use

            Lactation: avoid use

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Saponins: aescin: vasoconstrictor; aesculin (a hydroxycoumarin)- antithrombin activity

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