Brand and Other Names:African chilies, Ausanil, more...capsaicin, cayenne, chili pepper, green chili pepper, Louisiana long pepper, Mexican chilies, paprika, pimento, red pepper, tabasco pepper
- Classes: Analgesics, Herbals
Apply 0.025%-0.075% TID-QID; min 4 weeks
May take up to 14 days for full analgesic effect
Avoid using near eyes or on sensitive skin
Wash hands after applying
Fruit: 30-120 PO TID
Tincture: 0.6-2 ml/dose PO
Oleoresin: 0.6-2 mg/dose PO
Migraine (Ausanil): Spray 1-2 times into nostril
Apply 0.025%-0.3% topically 4-6 x/day
Post-herpetic pain (shingles)
Circulatory problems (peripheral), clotting disorders, diarrhea, digestion problems, fibromyalgia (topical), heart disease (prevention), neuralgias (topical), neuropathies (topical), pain syndromes (topical), prurigo nodularis
Effective for pain relief
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Local burning sensation
Mucous membrane irritation
Urticaria (topical use)
Damaged skin (topical use), hypersensitivity to peppers, infectious GI conditions (oral use), inflammatory GI conditions (oral use), open wounds (topical use)
Concurrent sedative meds
Avoid touching eyes, nose, mouth, etc. after topical application until it is washed off
Do not apply external heat after topical capsaicin application
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Active constituent, capsaicin, binds to neuronal transient potential vanilloid receptor 1 (TPRV1), depletes substance P; decreases pain perception