Brand and Other Names:afrikanische teufelskralle, ao ao, more...arpagofito, Arthrosetten H, Arthrotabsm, artiglio del diavolo, Artosan, Defencid, Doloteffin, duiwelsklou, ekatata, elyata, grapple plant, griffe du diable, Hariosen, Harpadol, HarpagoMega, harpagon, harpagophytum procumbens, harpagoside, Jucurba N, khams, khuripe, klaudoring, likakata, otjihangatene, RheumaSern, RheumaTee, Salus, sengaparile, Sudafrikanische Teufelskralle, Trampelklette, Venustorn, windhoek's root, wood spider, xemta'eisa
Osteoarthritis/Low Back Pain
Crude Extract: 2-9 g/d PO
Standardized Tablets: 600-1200 mg (=50-100 mg harpagoside) PO TID
Anorexia: 1.5 g/day decoction
Elixir (1:1): 0.1-0.25 mL PO TID
Osteoarthritis, lower back pain, appetite loss, cancer pain
Increasing evidence of short-term benefit in osteoarthritis; some evidence of benefit in lower back pain; unclear with regards to other uses
Extensively used in Europe for mild joint pain
German Commission E approves the use of Devil's claw root for:
- Appetite loss, dyspepsia, supportive therapy for arthritis
ESCOP approves the use of Devil's claw root for:
- Painful arthrosis, tendinitis, appetite loss, dyspepsia
Serious - Use Alternative
Significant - Monitor Closely
Headache, GI upset, bradycardia, taste loss
Stomach or intestinal ulcer, diabetes, high or low blood pressure, arrhythmia
Safety/efficacy not established for children
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Unclear; one study found correlation between serum harpagoside levels & leukotriene biosynthesis inhibition; harpagoside may also have analgesic actions
May also have anti-oxidant effects
Constituents include iridoid glucosides (eg, harpagoside), phytosterols, & flavonoids