Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

aspirin/dipyridamole (Rx)Brand and Other Names:Aggrenox

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

aspirin/dipyridamole

capsule, extended release

  • 25mg/200mg
more...

Stroke

Secondary prophylaxis of transient ischemic attack (TIA) or cerebrovascular accident (CVA)

1 capsule PO q12hr

Dosing considerations

  • Not interchangeable with individual components of aspirin/dipyridamole
  • Intolerable headaches during initial treatment: Switch to 1 capsule PO at bedtime; patient should return to normal regimen when possible (usually 1 week)

Dosing Modifications

GFR <10 mL/min: Use not recommended

Administration

Swallow capsules whole, without chewing

Safety and efficacy not established

Next

Interactions

Interaction Checker

aspirin/dipyridamole and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            >10%

            Headache (10-39%)

            Dyspepsia (4-18%)

            Abdominal pain (4-18%)

            Nausea (6-16%)

            Diarrhea (13%)

            1-10%

            Vomiting (3-8%)

            Pain (6%)

            Fatigue (6%)

            Arthralgia (5%)

            Back pain (5%)

            Hemorrhage, nonspecific (3%)

            Accidental injury (3%)

            Epistaxis (3%)

            Amnesia (3%)

            Arthritis (2%)

            Melena (2%)

            Asthenia (2%)

            Convulsions (2%)

            Neoplasm, nonspecific (2%)

            Anemia (2%)

            Rectal hemorrhage (2%)

            Malaise (2%)

            Cardiac failure (2%)

            Coughing (2%)

            Purpura (1%)

            GI hemorrhage (1%)

            Anorexia (1%)

            Somnolence (1%)

            Myalgia (1%)

            Arthrosis (1%)

            Confusion (1%)

            Hemorrhoids (1%)

            Syncope (1%)

            Upper respiratory tract infection (1%)

            Postmarketing Reports

            Body as whole: Hypothermia, chest pain

            Cardiovascular: Angina pectoris

            CNS: Cerebral edema

            Fluid and electrolyte: Hyperkalemia, metabolic acidosis, respiratory alkalosis, hypokalemia

            GI: Pancreatitis, Reye syndrome, hematemesis

            General: Hearing loss, anorexia, aplastic anemia, migraine, pancytopenia, thrombocytosis, allergic vasculitis, prothrombin time (PT) prolongation, disseminated intravascular coagulation (DIC), coagulopathy, thrombocytopenia

            Immune: Hypersensitivity, acute anaphylaxis, laryngeal edema

            Hepatic: Hepatitis, hepatic failure

            Musculoskeletal: Rhabdomyolysis

            Metabolic: Hypoglycemia, dehydration

            Reproductive: Prolonged pregnancy and labor, stillbirths, lower-birth-weight infants, antepartum and postpartum bleeding

            Respiratory: Tachypnea, dyspnea

            Skin: Rash, alopecia, angioedema, Stevens-Johnson syndrome, skin hemorrhage (eg, bruising, ecchymosis, hematoma)

            Urogenital: Interstitial nephritis, papillary necrosis, proteinuria

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity to aspirin, dipyridamole, or NSAIDs

            Syndrome of asthma, rhinitis, and nasal polyps

            Children younger than 16 years with viral infections (risk of Reye syndrome)

            Cautions

            Discontinue if tinnitus or impaired hearing occurs

            Use with caution in patients with cardiovascular or GI diseases or bleeding disorders

            Risk of precipitation of chest pain in patients with underlying coronary artery disease (CAD)

            Dosage in drug may not be adequate in patients with history of stroke or TIA for whom aspirin is indicated to prevent recurrent MI or angina pectoris

            Preexisting hypotension may be exacerbated by peripheral vasodilation

            Increased bleeding risk when drug coadministered with antiplatelet agents (eg, anagrelide), anticoagulants (eg, heparin), fibrinolytic agents, or NSAIDs (in long-term use)

            When possible, surgical patients should not receive aspirin 2 weeks before undergoing a surgical procedure

            Increased bleeding risk with chronic heavy alcohol use (>3 alcoholic drinks/day)

            Risk of elevated liver function test values or hepatic failure with dipyridamole administration

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy category: D

            Lactation: Drug enters breast milk; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Aspirin: Inhibits platelet cyclooxygenase and thus inhibits generation of thromboxane A2, a powerful inducer of platelet aggregation and vasoconstriction, leading to abrogation of platelet aggregation

            Dipyridamole: Inhibits uptake of adenosine into platelets, endothelial cells, and erythrocytes 

            Combination of aspirin and dipyridamole produces additive antiplatelet effects 

            Absorption

            Peak plasma levels: Dipyridamole, 2 hr

            Distribution

            Protein bound: Dipyridamole, 99%

            Vd: Dipyridamole, 92 L

            Metabolism

            Metabolized by liver: Dipyridamole

            Elimination

            Dipyridamole: Feces (95%), urine (5%)

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.