Chasteberry (Herbs/Suppl)

Brand and Other Names:agnolyt, agnus castus, more...chaste tree, hemp tree, monks pepper, vitex agnus castus
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Suggested Dosing

Crude herb extract

20-240 mg/d div BID-TID PO

Fluid extract

40 gtt/d PO

Dried fruit extract

1.6-3 mg PO BID

Tincture

35-45 gtt PO TID

Other Information

PMS: 4-20 mg/d

PMDD: 20-40 mg/d

No more than 1800 mg/d

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Suggested Uses

Acne, benign prostatic hyperplasia, fibrocystic breast disease, impotence, infertility (female), lactation, menopausal symptoms, menstrual irregularities, premenstrual syndrome, progesterone insufficiency

Efficacy

RCT (BMJ 2001;322:134-137) demonstrated benefit vs. placebo

Possibly effective for treating premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS).

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Interactions

Interaction Checker

and Chasteberry

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Acne

            Agitation

            Allergic reactions

            Alopecia

            Dry mouth

            GI upset

            Headache

            Intramenstrual bleeding

            Itching

            Menstrual flow changes

            Nausea

            Rash

            Tachycardia

            Tiredness

            Urticaria

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            Warnings

            Contraindications

            Breast cancer, endometriosis, hormone sensitive conditions, ovarian cancer, uterine cancer, uterine fibroids

            Cautions

            In vitro fertilization

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            Pregnancy & Lactation

            Pregnancy Category: unsafe

            Lactation: unsafe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Increase progesterone:estrogen ratio by decreasing FSH release

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