Crude herb extract
20-240 mg/d div BID-TID PO
40 gtt/d PO
Dried fruit extract
1.6-3 mg PO BID
35-45 gtt PO TID
PMS: 4-20 mg/d
PMDD: 20-40 mg/d
No more than 1800 mg/d
Acne, benign prostatic hyperplasia, fibrocystic breast disease, impotence, infertility (female), lactation, menopausal symptoms, menstrual irregularities, premenstrual syndrome, progesterone insufficiency
RCT (BMJ 2001;322:134-137) demonstrated benefit vs. placebo
Possibly effective for treating premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS).
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Menstrual flow changes
Breast cancer, endometriosis, hormone sensitive conditions, ovarian cancer, uterine cancer, uterine fibroids
In vitro fertilization
Pregnancy & Lactation
Pregnancy Category: unsafe
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Increase progesterone:estrogen ratio by decreasing FSH release