- 200-400 mg PO TID
- 600-7200 mg/d PO
- 4 g (approx 1 clove) PO qD
Topical (Liquefied raw Garlic or Extract)
Apply to affected area TID
CAD (prevention), cancer (prevention), circulation (enhancement), Helicobacter pylori infection, hyperlipidemia, hypertension, immunostimulant, menstrual disorders, tick repellant, tinea infections
Some conflicting data on serum lipid reduction; overall shown to be "modestly" effective in decreasing serum cholesterol
Demonstrated to lower systolic & diastolic BP
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Contact dermatitis (topical use)
Eczema (topical use)
Bleeding disorders, surgery within 1-2 weeks
Concurrent CYP 3A4 substrates, diabetes mellitus, GI infection, inflammatory bowel disease
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Decrease in cholesterol: 8-16 weeks
Hypotensive effects: 1-6 month
Mechanism of Action
Active constituent: allicin
Inhib. cholesterol biosynthesis
Inhib. platelet aggregation, thromboxane synthesis, lysosomal enzyme release; decr vascular musc. tone
Possible interference w/microbial structure, function