Garlic (Herbs/Suppl)

Brand and Other Names:ail, ajo, more...Allium sativum, camphor of the poor, da-suan, knoblauch, la-suan, nectar of the Gods, poor man's treacle, rust treacle, stinking rose
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Suggested Dosing

Oral

Standardized extract

  • 200-400 mg PO TID

Aged extract

  • 600-7200 mg/d PO

Fresh

  • 4 g (approx 1 clove) PO qD

Topical (Liquefied raw Garlic or Extract)

Apply to affected area TID

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Suggested Uses

CAD (prevention), cancer (prevention), circulation (enhancement), Helicobacter pylori infection, hyperlipidemia, hypertension, immunostimulant, menstrual disorders, tick repellant, tinea infections

Efficacy

Some conflicting data on serum lipid reduction; overall shown to be "modestly" effective in decreasing serum cholesterol

Demonstrated to lower systolic & diastolic BP

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Interactions

Interaction Checker

and Garlic

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Anaphylaxis

            Angioedema

            Asthma

            Bleeding

            Conjunctivitis

            Contact dermatitis (topical use)

            Diarrhea

            Eczema (topical use)

            Flatulence

            GI irritation/burning

            GI upset

            Heartburn

            Nausea/vomiting

            Rhinitis

            Urticaria

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            Warnings

            Contraindications

            Bleeding disorders, surgery within 1-2 weeks

            Cautions

            Concurrent CYP 3A4 substrates, diabetes mellitus, GI infection, inflammatory bowel disease

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            Pregnancy & Lactation

            Pregnancy Category: N/A

            Lactation: N/A

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Decrease in cholesterol: 8-16 weeks

            Hypotensive effects: 1-6 month

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Active constituent: allicin

            Inhib. cholesterol biosynthesis

            Inhib. platelet aggregation, thromboxane synthesis, lysosomal enzyme release; decr vascular musc. tone

            Possible interference w/microbial structure, function

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