Dosing & Uses
Dosage Forms & Strengths
topical ointment (AkneMycin)
topical pads (Ery)
Apply topically BID (morning and evening) to affected areas after skin is thoroughly washed and patted dry
Safety and efficacy not established
Frequency Not Defined
For external use only; avoid contact with eyes and mucous membranes
Concomitant topical acne therapy may result in cumulative irritation, especially with the use of peeling, desquamating, or abrasive agents; if this occurs, discontinue and seek medical advice
Although limited systemic absorption occurs with topical erythromycin, antibiotics may be associated with the overgrowth of nonsusceptible organisms; if this occurs, discontinue use and contact physician
Pregnancy & Lactation
Pregnancy Category: B
Lactation: Unknown if excreted in breast milk; use with caution
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
The exact mechanism by which erythromycin reduce lesions of acne vulgaris is not fully known
Erythromycin: Inhibits protein synthesis in susceptible organisms by reversibly binding to 50 S ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis
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