pemirolast ophthalmic (Discontinued)

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Brand and Other Names:Alamast

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.1% (1mg/mL)
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Allergic Conjunctivitis

Instill 1-2 gtt in affected eye(s) four times daily

Treatment duration ranges between a few days up to 4 weeks

Dosage Forms & Strengths

ophthalmic solution

  • 0.1% (1 mg/mL)
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Allergic Conjunctivitis

<3 years: Safety and efficacy not established

>3 years: As adults; instill 1-2 gtt in affected eye(s) four times daily

Treatment duration ranges between a few days up to 4 weeks

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Adverse Effects

1-10%

Burning

Dry eyes

Foreign body sensation

Ocular discomfort

Allergy

Bronchitis

Cough

Sneezing

Nasal congestion

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Warnings

Contraindications

Hypersensitivity

Cautions

For ophthalmic use only

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Distributed in breast milk; caution advised

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Mast cell stabilizer; inhibits type-I immediate hypersensitivity reaction; also may inhibit mast cell release of inflammatory mediators and chemotaxis of eosinophils

Pharmacokinetics

Half-Life: 4.5 hr (systemic measurement after 2 weeks of ophthalmic administration)

Peak Plasma Time: 0.4 hr  

Peak Plasma Concentration: 4.7 ng/mL (after 2 weeks of ophthalmic administration

Excretion: Urine (10-15% unchanged)  

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