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interferon alfa n3 (Rx)Brand and Other Names:Alferon N

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

injectable solution

  • 5 million unit/mL
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Condylomata Acuminata (Genital Warts)

250,000 unit (0.05 mL) per wart intralesional inj 2 times/week up to 8 weeks; not to exceed 2.5 million unit (0.5 mL) per treatment session

Do not administer any treatment for at least next 3 months unless warts enlarge or new appear

Administer into base of wart; for large warts, several points around periphery of wart may be used for total dose of 0.05 mL

<18 years old: safety & efficacy not established

Condylomata Acuminata (Genital Warts)

250,000 unit (0.05 mL) per wart intralesional inj 2 times/week up to 8 weeks; not to exceed 2.5 million unit (0.5 mL) per treatment session

Do not administer any treatment for at least next 3 months unless warts enlarge or new ones appear

Administer into base of wart; for large warts, several points around periphery of wart may be used for total dose of 0.05 mL

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Interactions

Interaction Checker

interferon alfa n3 and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Myalgia (45%)

            Fever (40%)

            Headache (31%)

            Chills (14%)

            Fatigue (14%)

            Decreased WBC

            1-10%

            Dizziness (9%)

            Depression

            Insomnia

            Pruritus

            Diarrhea

            Dyspepsia

            Taste disturbance

            Nausea/vomiting

            Nose bleed

            Groin and lymph node swelling

            Pharyngitis

            Arthralgia

            Visual disturbance

            Back pain

            Paresthesia

            Thirst

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            Warnings

            Contraindications

            Hypersensitivity to human interferon alpha proteins, mouse IgG, egg proteins, or neomycin

            Cautions

            Use caution in cardiovascular disease, severe pulmonary disease, diabetes mellitus with ketoacidosis, coagulopathies, severe myelosuppression, seizure disorder

            Discontinue immediately if anaphylactic reactions develop

            Safety/efficacy of repeat course not established

            Theoretical remote possibility of pathogen transmission from albumin present in the solution

            Do not change brands of interferon

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known whether excreted in breast milk, do not nurse or do not initiate treatment

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Immunomodulating cytokine; may interfere with oncogene expression, induce gene transcription, may alter cellular differentiation and cell surface antigen expression , may increase phagocytic activity of macrophages, may inhibit cell growth

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            Images

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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