citric acid/sodium bicarbonate (OTC)Brand and Other Names:Alka-Seltzer Heartburn Relief

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

citric acid/sodium bicarbonate

effervescent tablet

  • 1000mg/1940mg
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Indigestion/Heartburn

Dissolve 2 tablets in water and drink effervescent solution q4hr PRN

Not to exceed 8 tablets/24 hr

Administration

Fully dissolve tablets in 4 oz of water before drinking

Dosage Forms & Strengths

citric acid/sodium bicarbonate

effervescent tablet

  • 1000mg/1940mg
more...

Indigestion/Heartburn

<12 years: Safety and efficacy not established

≥12 years: Dissolve 2 tablets in water and drink effervescent solution q4hr PRN; not to exceed 8 tablets/24 hr

Administration

Fully dissolve tablets in 4 oz of water before drinking

Indigestion/Heartburn

Dissolve 2 tablets in water and drink effervescent solution q4hr PRN

Adults >60 years: Not to exceed 4 tablets/24 hr

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Interactions

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citric acid/sodium bicarbonate and

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    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Warnings

            Contraindications

            None

            Cautions

            Sodium-restricted diet; 575 mg sodium/tablet

            Phenylketonurics; contains phenylalanine 5.6 mg/tablet

            Discontinue if taken maximum dosage for 2 weeks without relief

            Alters gastric pH and may interfere with absorption of some concurrent medications

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Unknown whether distributed in breast milk

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Citric acid: Antacid; forms sodium citrate which neutralizes stomach acid

            Sodium bicarbonate: Antacid; reacts with and neutralizes hydrochloric acid in the stomach

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