aspirin/citric acid/sodium bicarbonate (OTC)

Brand and Other Names:Alka Seltzer Original
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

aspirin/citric acid/sodium bicarbonate

effervescent tablet

  • 325mg/1000mg/1916mg
more...

Antacid & Analgesic

Indicated for heartburn, acid indigestion, and sour stomach when accompanied with headache or body aches

2 tablets (dissolved in water) PO q4hr PRN; not to exceed 8 tablets/day (see Administration)

Age >60 years old: Do not exceed 4 tablets/day (see Cautions)

Dosage Forms & Strengths

aspirin/citric acid/sodium bicarbonate

effervescent tablet

  • 325mg/1000mg/1916mg
more...

Antacid & Analgesia

<12 years old: Safety and efficacy not established

≥12 years: As adults; 2 tablets (dissolved in water) PO q4hr PRN; not to exceed 8 tablets/day (see Administration)

Next:

Interactions

Interaction Checker

and aspirin/citric acid/sodium bicarbonate

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 
            Previous
            Next:

            Adverse Effects

            Frequency Not Defined

            Flatulence

            Rebound hyperacidity

            Stomach cramps

            Vomiting

            Previous
            Next:

            Warnings

            Contraindications

            Hypocalcemia, hypochloremia, respiratory alkalosis

            Hypersensitivity to aspirin or any component

            Cautions

            History of: CHF, renal impairment, hypertension

            Use of salicylates in pediatric patients with varicella or influenza-like illness is associated with increased incidence of Reye Syndrome

            Bleeding risk

            • Higher doses or use for a longer period than recommended increases risk of serious bleeding
            • Risk increased with ≥1 of the following
              • Age ≥60 yr
              • History of stomach ulcers or bleeding problems
              • Coadministration or anticoagulant or corticosteroids
              • Coadministration with other NSAIDs Consumes ≥3 alcoholic drinks every day
            Previous
            Next:

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unknown

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next:

            Pharmacology

            Mechanism of Action

            Gastric acid neutralization and analgesia by inhibiting prostaglandin synthesis by cyclooxygenase

            Pharmacokinetics

            Onset: PO, as antacid: 15 min

            Duration: PO: 1-3 hr

            Bioavailability: 4-45%, food increases absorption 10-30%

            Protein Bound: 45%

            Metabolism: in the presence of stomach acid, bicarbonate ion forms carbon dioxide and water, sodium and excess bicarbonate are absorbed into plasma

            Excretion: reabsorbed by kidney, <1% excreted in urine

            Previous
            Next:

            Administration

            Oral Administration

            Fully dissolve 2 tablets in 4 oz of water before orally ingesting

            Previous
            Next:

            Images

            Previous
            Next: