diphenhydramine/allantoin topical (OTC)

Brand and Other Names:Allegra Anti-Itch Cooling Relief Cream, Allegra Anti-Itch Intensive Relief Cream
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

diphenhydramine/allantoin

topical cream

  • 2%/0.5%
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Itching

Temporarily relieves pain and itching associated with insect bites, minor skin irritations, sunburn, rashes, or minor burns, cuts, or scrapes

Apply to affected area PRN; not to exceed 3-4 applications/day

Administration

Avoid eyes

Dosage Forms & Strengths

diphenhydramine/allantoin

topical cream

  • 2%/0.5%
more...

Itching

Temporarily relieves pain and itching associated with insect bites, minor skin irritations, sunburn, rashes, or minor burns, cuts, or scrapes

<2 years: Safety and efficacy not established

≥2 years: Apply to affected area PRN; not to exceed 3-4 applications/day

Administration

Avoid eyes

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Warnings

Contraindications

Hypersensitivity

Cautions

Do not use more than directed

Do not use large areas of the body

Do not use with other diphenhydramine products, including oral products

Do not use on deep or puncture wounds, animal bites, or serious burns

Do not use on serious sunburn or broken, blistered or oozing skin

Advise patient to contact physician if condition worsens or symptoms persist beyond 7 days

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Unknown whether distributed in breast milk

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Diphenhydramine: Histamine H1-receptor antagonist; elicits topical anesthetic effects

Allantoin: Skin protectant

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