pseudoephedrine/fexofenadine (OTC)Brand and Other Names:Allegra D, Allegra-D 12 Hour Allergy & Congestion, more...Allegra-D 24 Hour Allergy & Congestion

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

pseudoephedrine/fexofenadine

tablet, extended-release 12 hr

  • 120mg/60mg

tablet, extented-release 24 hr

  • 240mg/180mg
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Seasonal Allergic Rhinitis with Nasal Congestion

12-Hour tab: 1 tab 60 mg fexofenadine/120 mg pseudoephedrine PO BID

24-Hour tab: 1 tab 180 mg fexofenadine/240 mg pseudoephedrine PO qDay

Renal Impairment

Avoid

Other Information

Take on empty stomach with water only

Swallow whole; do not chew, crush, or split tablet

Dosage Forms & Strengths

pseudoephedrine/fexofenadine

tablet, extended-release 12 hr

  • 120mg/60mg

tablet, extended-release 24 hr

  • 240mg/180mg
more...

Seasonal Allergic Rhinitis with Nasal Congestion

<12 years: Safety and efficacy not established

12 years or older: As adults

12-Hour tab: 1 tab 60 mg fexofenadine/120 mg pseudoephedrine PO BID

24-Hour tab: 1 tab 180 mg fexofenadine/240 mg pseudoephedrine PO qDay

Renal Impairment

Avoid

Other Information

Take on empty stomach with water only

Swallow whole; do not chew, crush, or split tablet

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Interactions

Interaction Checker

pseudoephedrine/fexofenadine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Varies in incidence & severity with the individual drug; also individual patients vary in susceptibility

            1-10%

            Headache (7.2%)

            Drowsiness (1.3%)

            Fatigue (1.3%)

            Frequency Not Defined

            CNS depression

            Sedation ranging from mild drowsiness to deep sleep (most frequent)

            Dizziness

            Lassitude

            Disturbed coordination

            Muscular weakness

            Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common

            Epigastric distress

            Anorexia

            Nausea

            Vomiting

            Diarrhea

            Constipation

            Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare

            Tachycardia, palpitation ECG changes (eg, widened QRS)

            Arrhythmias (eg, extrasystole, heart block)

            Hypotension

            Hypertension

            Dizziness, sedation, and hypotension may occur in geriatric patients

            Dryness of mouth, nose, and throat

            Dysuria

            Urinary retention

            Impotence

            Vertigo

            Visual disturbances

            Blurred vision

            Diplopia; tinnitus

            Acute labyrinthitis

            Insomnia

            Tremors

            Nervousness

            Irritability

            Facial dyskinesia

            Tightness of the chest

            Thickening of bronchial secretions

            Wheezing

            Nasal stuffiness

            Sweating

            Chills

            Early menses

            Toxic psychosis

            Faintness

            Paresthesia

            Agranulocytosis

            Hemolytic anemia

            Leukopenia

            Thrombocytopenia

            Pancytopenia

            Dysmenorrhea

            Dyspepsia

            Fatigue

            Ischemic colitis (pseudoephedrine)

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            Warnings

            Contraindications

            Documented hypersensitivity to drug or ingredients

            Premature newborns and neonates

            Nursing women

            Cautions

            Wax from external release pseudoephedrine may appear in stool

            Caution in narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, or bladder neck obstruction

            Severe renal impairment

            Giving with fruit juice may decrease efficacy

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: avoid, not known if enters breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Fexofenadine: H1 histamine receptor antagonist; metabolite of terfenadine

            Pseudoephedrine: Alpha adrenergic agonist

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