Feverfew (Herbs/Suppl)

Brand and Other Names:altamisa, bachelor button, more...camomille grande, chrysanthemum parthenium, featherfew, featherfoil, flirtwort midsummer daisy, midsummer daisy, Santa Maria, tanacetum parthenium
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Suggested Dosing

Migraine, Prophylaxis

Extract

  • 50-100 mg PO daily

Fresh leaf

  • 2.5 leaves PO daily

Freeze dried leaf

  • 50-150 mg PO qD-BID
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Suggested Uses

Prevention, control of migraine prophylaxis

Allergies, arthritis, fevers, headaches, menstrual irregularities, migraine prophylaxis, psoriasis, tinnitus, vertigo, cancer

Efficacy

Demonstrated effective to decr severity/frequency of migraine

Not established for rheum. arthritis, other inflammatory conditions (higher doses may be necessary)

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Interactions

Interaction Checker

and Feverfew

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Abdominal pain

            Allergic reaction

            Diarrhea

            Flatulence

            Indigestion

            Mouth ulcers

            Nausea/vomiting

            Anxiety (chronic use)

            Headache (chronic use)

            Insomnia (chronic use)

            Muscle/joint stiffness (chronic use)

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            Warnings

            Contraindications

            Lactation, pregnancy, ragweed allergies

            Hypersensitivity to Asteraceae/Compositae plants

            Hypersensitivity to chrysanthemums, daisies, marigolds

            Cautions

            Quality of products vary widely; depends on content of parthenolide

            Min. parthenolide content should be 0.2

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            Pregnancy & Lactation

            Pregnancy Category: unsafe

            Lactation: unsafe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Sesquiterpene lactones, incl. parthenolide: inhib. release of arachidonic acid

            Inhib. platelet and leukocytes secretion of serotonin, histamine

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