- 50-100 mg PO daily
- 2.5 leaves PO daily
Freeze dried leaf
- 50-150 mg PO qD-BID
Prevention, control of migraine prophylaxis
Allergies, arthritis, fevers, headaches, menstrual irregularities, migraine prophylaxis, psoriasis, tinnitus, vertigo, cancer
Demonstrated effective to decr severity/frequency of migraine
Not established for rheum. arthritis, other inflammatory conditions (higher doses may be necessary)
Serious - Use Alternative
Significant - Monitor Closely
Frequency Not Defined
Anxiety (chronic use)
Headache (chronic use)
Insomnia (chronic use)
Muscle/joint stiffness (chronic use)
Lactation, pregnancy, ragweed allergies
Hypersensitivity to Asteraceae/Compositae plants
Hypersensitivity to chrysanthemums, daisies, marigolds
Quality of products vary widely; depends on content of parthenolide
Min. parthenolide content should be 0.2
Pregnancy & Lactation
Pregnancy Category: unsafe
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Sesquiterpene lactones, incl. parthenolide: inhib. release of arachidonic acid
Inhib. platelet and leukocytes secretion of serotonin, histamine