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aluminum hydroxide (OTC)Brand and Other Names:AlternaGEL, Amphojel, more...Nephrox

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral suspension

  • 320mg/5mL
more...

Antacid

5-30 mL PO between meals & HS or as directed

Peptic Ulcer Disease

5-30 mL between meals & HS or as directed

Hyperphosphatemia

300-600 mg PO 3 times/day between meals and HS

Administration

Follow dosing with water

Dosage Forms & Strengths

oral suspension

  • 320mg/5mL
more...

Hyperphosphatemia

50-150 mg/kg/day divided q4-6hr PO; titrate dose to keep phosphorus within normal range

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Interactions

Interaction Checker

aluminum hydroxide and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Nausea

            Vomiting

            Rebound hyperacidity

            Aluminum-intoxication

            Hypophosphatemia

            Chalky taste

            Constipation

            Fecal impaction

            Stomach cramps

            Milk-alkali syndrome

            Osteomalacia

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            Warnings

            Contraindications

            Hypersensitivity to aluminum salts

            Cautions

            Aluminum toxicity may occur in renal failure patients

            Hypophosphatemia may occur

            Use caution in patients with heart failure, cirrhosis, edema, or renal failure

            Will bind calcium if given at same time

            Elderly may be predisposed to fecal impaction

            Use caution in patients who have recently suffered massive gastrointestinal hemorrhage

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not known whether aluminum hydroxide is excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Antacid: Neutralizes HCl in the stomach to form soluble aluminum chloride

            Phosphate binder: binds phosphate in the GI tract to form insoluble complexes and reduces phosphate absorption

            Pharmacokinetics

            Excretion

            • Absorbed aluminum is eliminated in the urine (0.1-0.5 mg of Al in aluminum-containing antacid is absorbed from standard daily doses of antacid)
            • Insoluble, poorly absorbed Al salts in the intestines: hydroxides, carbonates, phosphates and fatty acid derivatives, are excreted in feces
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