Whole berries: 1-2 g PO daily
Lipophilic extract: 320 mg/day PO qD OR 160 mg PO BID
Standardized extracts 100-400 mg PO BID
BPH, diuretic, a sedative, an anti-inflammatory, alopecia, prostate cancer (in combo with other herbs), and antiseptic
BPH: Saw palmetto fruit extract did not reduce lower urinary tract symptoms more than placebo 2 trial randomized controlled trials (JAMA. 2011 Sept 28;306:1289-1395) (N Engl J Med. 2006;354:557-566)
Insufficient reliable test results to determine efficacy for other suggested uses
Serious - Use Alternative
Significant - Monitor Closely
Nausea, headache (rare)
Diarrhea (high doses)
Pregnant women should avoid contact: potential for transdermal absorption, or exposure from semen
Pregnancy & Lactation
Pregnancy Category: avoid use
Lactation: avoid use
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Active constituents: sitosterols; anthranilic, caffeic, chlorogeneic acids
Inhibits 5-alpha-reductase conversion of testosterone to dihydrotestosterone
Anti-inflammatory inhibition of cycloxygenase, lipoxygenase pathways