Saw Palmetto (Herbs/Suppl)

Brand and Other Names:American dwarf palm tree, cabbage palm (saw palmetto), more...dwarf palm, juzhong, palmier nain, sabal fructus, sabal serrulata, serenoa repens, serenoa serrulata
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Suggested Dosing

Whole berries: 1-2 g PO daily

Lipophilic extract: 320 mg/day PO qD OR 160 mg PO BID

Standardized extracts 100-400 mg PO BID

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Suggested Uses

BPH, diuretic, a sedative, an anti-inflammatory, alopecia, prostate cancer (in combo with other herbs), and antiseptic

Efficacy

BPH: Saw palmetto fruit extract did not reduce lower urinary tract symptoms more than placebo 2 trial randomized controlled trials (JAMA. 2011 Sept 28;306[12]:1289-1395) (N Engl J Med. 2006;354[6]:557-566)

Insufficient reliable test results to determine efficacy for other suggested uses

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Interactions

Interaction Checker

and Saw Palmetto

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Nausea, headache (rare)

            Diarrhea (high doses)

            Hepatotoxic potential

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            Warnings

            Contraindications

            Pregnant women should avoid contact: potential for transdermal absorption, or exposure from semen

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            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: avoid use

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Active constituents: sitosterols; anthranilic, caffeic, chlorogeneic acids

            Inhibits 5-alpha-reductase conversion of testosterone to dihydrotestosterone

            Anti-inflammatory inhibition of cycloxygenase, lipoxygenase pathways

            Pharmacokinetics

            Metabolism: N/A

            Excretion: N/A

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