aminohippurate sodium (Rx)

Brand and Other Names:para-aminohippurate (PAH)
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injectable solution

  • 20%
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Renal Function Diagnostic

Used for estimation and measurement of renal function (effective renal plasma flow and tubular secretion)

Goal is to maintain plasma concentration of 2 mg/dL

Load 6-10 mg/kg, infuse at 10-24 mg/min 

Safety and efficacy not established

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Interactions

Interaction Checker

and aminohippurate sodium

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Patients have sensations of warmth or desire to defecate or urinate during or after infusion

            Hypersensitivity reactions

            • Angioedema, flushing, vasomotor disturbances
            • Tingling
            • Urticaria
            • Nausea, vomiting & cramps
            • Anaphylaxis
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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            Low cardiac reserve

            Latex sensitive individuals: Vial stopper contains dry natural latex

            Administer IV solutions with caution to patients with low cardiac reserve (rapid increase in plasma volume may precipitate congestive heart failure

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown; use caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Undergoes glomerular filtration; ~90% proximal tubular secretion in a single circulation

            Used to measure the functional activity of the renal tubular secretory mechanism or transport maximum (TmPAH)

            Pharmacokinetics

            Renal Clearance: ~90% in a single circulation at low plasma concentrations

            Excretion: Urine

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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