aspirin/caffeine (OTC)

Brand and Other Names:Anacin Maximum Strength, Bayer Extra Strength Back & Body Pain, more...Bayer AM, Bayer Headache Relief, BC Powder, BC Powder Arthritis Strength, Blowfish, Alka-Seltzer Wake-Up Call Effervescent, Anacin, P-A-C, Painaid ESF Extra-Strength Formula Tablets, Summit Extra Strength Caplets
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

asprin/caffeine

tablet

  • 250mg/65mg
  • 400mg/32mg
  • 500mg/32mg
  • 500mg/32.5mg

caplet

  • 250mg/65mg

tablet, effervescent

  • 500mg/65mg

powder

  • 845mg/65mg
  • 1000mg/65mg

quick release crystals

  • 850mg/65mg
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Analgesia

1-2 tablets/caplet/powders PO q4-6hr PRN

Products vary, check specific labeling for each

Hangover

The brand Blowfish is indicated for temporary relief of minor aches and pains associated with a hangover, helps restore mental alertness or wakefulness when fatigue or drowsiness is associated with a hangover (also indicated for headaches and other mild analgesic needs)

Blowfish: Dissolve 1,000 mg/120 mg (2 effervescent tabs) in 16 oz of water and drink q6hr prn; not to exceed 8 tablets/24 hr

Each effervescent tablet of Blowfish contains 500 mg of aspirin and 60 mg of caffeine

≥60 years: Dissolve 2 effervescent tabs in 16 oz of water and drink contents, may repeat dose after 6 hr; not to exceed 4 tabs/24 hr

Safety and efficacy not established

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Interactions

Interaction Checker

and aspirin/caffeine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Aspirin

            • Dyspepsia
            • Heartburn
            • Nausea
            • Vomiting
            • Stomach pain
            • Tinnitus (high or chronic dose)
            • Rash

            Caffeine

            • Insomnia
            • Irritability
            • Angina
            • Chest pain
            • Sinus tachycardia
            • Vasodilation
            • Urticaria
            • Psychosis
            • Decreased tone of esophageal sphincter
            • Nervousness
            • Restlessness
            • Tremor
            • Tinnitus
            • Nausea
            • Vomiting
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            Warnings

            Contraindications

            Hypersensitivity

            Asthma, rhinitis, nasal polyps, viral infections in children <16 years

            Cautions

            Gastrointestinal bleeding; particular caution in patients with history of GI bleed, alcoholism, or bleeding disorders

            Avoid with active peptic ulcer disease

            Avoid in severe renal impairment (ie, CrCl <10 mL/min)

            Avoid in severe hepatic impairment

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            Pregnancy & Lactation

            Pregnancy category: D; avoid during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

            Lactation: Excreted in breast milk; do not breast feed

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Aspirin: Acts on hypothalamus to produce antipyresis; anti-inflammatory properties attributed to prostaglandin synthetase inhibition resulting in decreased formation of thromboxane A2

            Caffeine: Vasoconstrictive properties may be helpful when treating vascular headaches

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            Images

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