1200 mg PO BID
Take with food
Diarrhea, hypercholesterolemia, hypertriglyceridemia, circulation improvement, indigestion
Efficacy: Possibly effective for hypercholesterolemia
Serious - Use Alternative
Significant - Monitor Closely
Abdominal discomfort, anaphylaxis (inhalation), dizziness, elevated creatine kinase, elevated liver enzymes, flatulence, gastritis, heartburn
Abnormal LFTs, liver dysfunction
Concurrent hepatotoxic agents
Pregnancy & Lactation
Pregnancy Category: avoid
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Rice fermented with Monascus purpureus yeast; contains small amounts of naturally-occurring lovastatin (mevinolin)