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vitamin E (OTC)Brand and Other Names:Aquasol E, alpha-tocopherol, more...tocopherol

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

capsule

  • 200units
  • 400units
  • 600units
  • 1000units

liquid

  • 400units/15mL

solution

  • 15units/0.3mL
more...

RDA

15 mg PO qDay; not to exceed 1000 mg/day

Pregnant Females

  • <18 years: 15 mg PO qDay; not to exceed 800 mg/day
  • >18 years: 15 mg PO qDay; not to exceed 1000 mg/day

Lactating Females

  • <18 years: 19 mg PO qDay; not to exceed 800 mg/day
  • >18 years: 19 mg/day PO qDay; not to exceed 1000 mg/day

Vitamin E Deficiency

60-75 units PO qDay

Postherpetic Neuralgia (Off-label)

400 units PO twice or four times daily

Administration

Swallow capsules whole, do not crush or chew

Dosage Forms & Strengths

capsule

  • 200units
  • 400units
  • 600units
  • 1000units

liquid

  • 400units/15mL

solution

  • 15units/0.3mL
more...

RDA

Swallow capsules whole, do not crush

1-3 years: 6 mg PO qDay; not to exceed 200 mg/day

3-8 years: 7 mg PO qDay; not to exceed 300 mg/day

8-13 years: 11 mg PO qDay; not to exceed 600 mg/day

13-18 years: 6 mg PO qDay; not to exceed 800 mg/day

Cystic Fibrosis Supplementation (Off-label)

1-12 months: 40-50 units/day

1-3 years: 80-150 units/day

4-8 years: 100-200 units/day

>8 years: 200-400 units/day

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Interactions

Interaction Checker

vitamin E and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Fatigue

            Headache

            Flatulence

            Diarrhea

            Blurred vision

            Necrotizing enterocolitis (infants)

            Increased serum creatinine

            Increased risk of hemorrhagic stroke

            Recent evidence suggests that Vitamin E may suppress action of other antioxidants

            Very modest but statistically significant increase in all-cause mortality with supplemental intake of vitamin E =400 IU/day

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            Warnings

            Contraindications

            Hypersensitivity to vitamin E or formulation components

            Cautions

            Vitamin E, at RDA levels, does not increase bleeding time or affect warfarin except at megadoses (~10x RDA or higher) - adjustment of warfarin may be necessary for such doses

            Discontinue high dose Vitamin E supplementation 1 month before surgery, may resume after recovery

            Use with caution in Vitamin K deficiency, bleeding propensity or lesions (bleeding peptic ulcers, hemophilia etc)

            Vitamin E increases efficacy & decreases toxicity of antineoplastic drugs

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            Pregnancy & Lactation

            Pregnancy Category: A (RDA levels)

            Lactation: Excreted in breast milk; safe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Nutrition

            Sources: Wheat germ oil, sunflower seeds; richest source is vegetable oils

            Functions: Lipid antioxidant, protects membrane phospholipids, intracellular antioxidant, inhibits platelet aggregation

            Deficiency: Rare; occurs in premature infants & those who cannot absorb fat; sterility; muscle weakness, visceral impairment; infants: anemia, nerve, eye & balance problems that may be permanent

            Toxicity: Extremely rare

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            Pharmacology

            Mechanism of Action

            Plays a role in protecting red blood cells against hemolysis; has protective effects against free radicals on polyunsaturated fatty acids found in cell membranes; plays a role in preventing oxidation of vitamin A and C

            Pharmacokinetics

            Absorption: Reduced in patients with history of malabsorption; water preparations better absorbed than oil preparations

            Distribution: All body tissues especially adipose tissues where it is stored

            Metabolism: Liver

            Excretion: Feces

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