artificial saliva (OTC)

Brand and Other Names:Oasis, Aquoral, more...SalivaSure, Caphosol, XyliMelts
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Dosing & Uses

AdultPediatric

Dosing Form & Strengths

Oral Spray

  • Oasis: Water, glycerin, sorbitol, poloxamer 338, PEG-60, hydrogenated castor oil, copovidone, sodium benzoate, carboxymethylcellulose (473 mL); ethanol free, sugar free, mild mint flavor
  • Aquoral: Oxidized glycerol triesters and silicon dioxide (40 mL); contains aspartame, delivers 400 sprays, citrus flavor
  • Mouth Kote: Water, xylitol, sorbitol, citric acid, yerba santa, ascorbic acid, sodium benzoate, sodium saccharin
  • Mol-Stir: Water, sodium carboxymethylcellulose, sorbitol, propylparaben, potassium chloride, dibasic sodium phosphate, magnesium chloride, sodium chloride, calcium chloride, methylparaben

Oral Solution

  • Caphosol: Dibasic sodium phosphate 0.032%, monobasic sodium phosphate 0.009%, calcium chloride 0.052%, sodium chloride 0.569%, purified water (30 mL); packaged in two 15 mL ampuls when mixed together provide one 30 mL dose
  • Entertainer's secret: Aloe vera gel, sodium carboxymethylcellulose, glycerin (60 mL); ethanol free; honey-apple flavor

Lozenge

  • SalivaSure: Xylitol, citric acid, apple acid, sodium citrate dihydrate, sodium carboxymethylcellulose, dibasic calcium phosphate, silica colloidal, magnesium stearate, stearic acid
  • Numoisyn: Sorbitol 0.3 g/lozenge; polyethylene glycol, calcium phosphate dibasic, hydrogenated cottonseed oil, silicon dioxide, magnesium stearate, citric acid, malic acid, sodium citrate

Liquid Oral

  • Numoisyn: Chondrus crispus, potassium sorbate, sorbitol, water, linseed extract, sodium benzoate, dipotassium phosphate, propylparaben, methylparaben

Gel

  • Biotene Oral Balance: Water, sunflower oil, starch, propylene glycol, glycerine, purified milk extract, xylitol (sugar free)

Discs Extended Release

  • XyliMelts: 500 mg xylitol: Dye free, gluten free, preservative free, soy free, yeast free

Powder For Reconstitution

  • NeutraSal: Chloride, silicon dioxide, bicarbonate, sodium, phosphates, calcium

Xerostomia

Caphosol, NeutraSal: Swish and spit; 2-10 doses/day

Oasis spray: 1-2 sprays PRN; not to exceed 60 sprays/day

Oasis mouthwash: Rinse mouth with ~30 mL q12hr PRN; do not swallow

Aquoral: 2 sprays PO q6-8hr PRN

Entertainer's secret: Spray PRN

Mouth Kote spray: Spray 3-5 times; swish for 8-10 seconds and spit or swallow PRN

Biotene: Apply 0.5 inch length onto tongue and spread evenly; repeat as often as needed

Numoisyn liquid: Use 2 mL PRN

Numoisyn lozenges: Dissolve 1 lozenge slowly; not to exceed 16 lozenges/day

SalivaSure: Dissolve 1 lozenge in mouth PRN; 1 lozenge/hr recommended

XyliMelts: Apply 2 discs before bed, 1 on each side of mouth, in lower or upper part of cheek; during the day, use as needed; swallow as it slowly dissolves (the tan, dimpled side will adhere to teeth or gums); before bedtime, use 2 discs, placing one on each side of the mouth

Not established

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Adverse Effects

Frequency Not Defined

Altered speech

Abnormal taste

Digestive problems

Dysphagia

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Warnings

Contraindications

Documented hypersensitivity

Fructose intolerance (Numoisyn lozenges)

Cautions

Caphosol contains 75 mg of sodium per 30 mL dose

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Pregnancy & Lactation

Pregnancy Category: A

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Mixture consisting of protein or electrolyte that lubricate, moisten and provide coating on oral mucosa used in absence of saliva

Xylitol stimulates saliva production

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