aspirin rectal (OTC)

Brand and Other Names:
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

suppository

  • 60mg
  • 120mg
  • 200mg
  • 300mg
  • 600mg
more...

Antipyretic/Analgesic

300-600 mg PR q4-6hr PRN

Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Dosage Forms & Strengths

suppository

  • 120mg
  • 200mg
  • 300mg
  • 600mg
more...

Antipyretic/Analgesic

<12 years: 10-15 mg/kg/dose PR q4-6hr; not to exceed 4 g/day

>12 years: As adults; 300-600 mg PR q4-6hr PRN

Geriatric Dosing

Antipyretic/Analgesic

  • <12 years: 10-15 mg/kg/dose PR q4-6hr; not to exceed 4 g/day
  • >12 years: As adults; 300-600 mg PR q4-6hr PRN

Renal Impairment

CrCl<10 mL: Not recommended

Hepatic Impairment

Not recommended

Administration

Patient should lie on left side with knees bent

Remove protective wrap before inserting

Gently insert tip into rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Antipyretic/Analgesic

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Interactions

Interaction Checker

and aspirin rectal

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     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Common

            • Rectal discomfort
            • Tinnitus (high or chronic dose)
            • Rash
            • Urticaria

            Angioedema

            DIC

            Hypotension

            Tachycardia

            CNS alteration

            Dizziness

            Headache

            Dermatologic problems

            Hives

            Electrolyte disturbances; dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis

            Platelet aggregation inhibition

            Prolonged prothrombin time

            Thrombocytopenia

            Hepatotoxicity

            Hearing loss

            Renal damage

            Bronchospasm

            Pulmonary edema (salicylate-induced/noncardiogenic)

            Reye syndrome

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            Warnings

            Contraindications

            Hypersensitivity to aspirin or NSAIDs

            Hepatitis or severe hepatic/renal impairment

            Do not use in children or adolescents with viral infections (eg, influenza, chickenpox) because of risk of Reye syndrome

            Cautions

            Many dosage forms, check label carefully!

            Gastrointestinal bleeding; particular caution in patients w/ history of GI bleed, alcoholism, or bleeding disorders

            Avoid w/ active peptic ulcer disease

            Avoid in severe renal impairment (ie, CrCl <10 mL/min)

            Avoid in severe hepatic impairment

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            Pregnancy & Lactation

            Pregnancy category: D; avoid during pregnancy, particularly in third trimester because of risk for premature closure of the ductus arteriosus

            Lactation: excreted in breast milk; do not breast feed

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Inhibits prostaglandin synthesis by cyclooxygenase-1 and -2 via acetylation; inhibits formation of prostaglandin derivative, thromboxane A2 via acetylation of platelete cyclooxygenase, which in turn inhibits platelet aggregation

            Pharmacokinetics

            Absorption: 60%

            Onset: 4-5 hr

            Half-life: 4.7-9 hr

            Protein Bound: 50-80%  

            Volume of Distribution: 150 mL/kg

            Metabolism: Hydrolyzed by esterases in liver (mostly) & erythrocytes to salicylic acid

            Metabolites: salicyluric acid, salicyl acyl glucuronide, salicyl phenolic glucuronide, gentisic acid

            Excretion: (urine) 5.6-35.6% Hemodialysis: Yes

            Pharmacogenomics

            Aspirin associated hypersensitivity reactions include:

            Aspirin-induced urticaria: associated with HLA-DRB1*1302-DQB1*0609 haplotype

            Aspirin-intolerant asthma: associated with HLA-DPB1*0301

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            Images

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