Variable oral doses
Estrogen replacement therapy, painful menstration, libido, breast enlargement, diverticulosis, dysmenorrhea, estrogen replacement, gallbladder colic, libido enhancement, osteoporosis, postmenopausal vaginal dryness, premenstrual syndrome, rheumatoid arthritis
Topically appears to be no better than placebo for relieving vasomotor symptoms
Orally: Possibly ineffective, more studies are needed to determine efficacy
Cancer (breast, ovarian, uterine), endometriosis, hormone sensitive conditions, uterine fibroids
Pregnancy & Lactation
Pregnancy Category: N/A
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Contains diosgenin, which can be converted to natural progesterone in vitro, but not in vivo
Diosgenin may stimulate mammary tissue growth, decrease GI inflammation, and weakly stimulate estrogen receptors