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atropine (Rx)Brand and Other Names:Atreza, Atropine PO, more...SalTropine

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 0.4mg
more...

Sialorrhea, Pylorospasm & Other Spastic Conditions of the Gastrointestinal Tract

0.4 mg PO q4-6hr PRN

Dosage Forms & Strengths

tablet

  • 0.4mg
more...

Sialorrhea, Pylorospasm & Other Spastic Conditions of the Gastrointestinal Tract

3-7 kg: 0.1 mg

8-11 kg: 0.15 mg

11-18 kg: 0.2 mg

18-29 kg: 0.3 mg

≥30 kg: 0.4 mg

Alternate Dosing

  • <5 kg: 0.02 mg/kg/dose initially, then q4-6hr PRN 
  • ≥5 kg: 0.01-0.02 mg/kg PO q4-6hr PRN; not less than 0.1 mg/dose, not to exceed 0.4 mg/dose
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Interactions

Interaction Checker

atropine and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Ataxia

            Coma

            Confusion

            Delirium

            Dizziness

            Drowsiness

            Hallucinations

            Headache

            Insomnia

            Nervousness

            Arrhythmia

            Flushing

            Hypotension

            Palpitation

            Tachycardia

            Dyspnea

            Laryngospasm

            Pulmonary edema

            Bloating

            Constipation

            Delayed gastric emptying

            Loss of taste

            Nausea

            Paralytic ileus

            Vomiting

            Xerostomia

            Nasal dryness

            Fever

            Anhidrosis

            Urticaria

            Rash

            Scarlantiniform rash

            Urinary hesitancy and retention

            Anaphylaxis

            Angle closure glaucoma

            Blurred vision

            Dry eyes

            Ocular pressure increased

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            Warnings

            Contraindications

            Hypersensitivity to anticholinergic drugs

            Narrow-angle glaucoma, synechia (adhesions) between iris and eye lens, myasthenia gravis, obstructive uropathy, paralytic ileus, severe ulcerative colitis, toxic megacolon, acute hemorrhage with cardiovascular instability, thyrotoxicosis

            Cautions

            Open-angle glaucoma, hyperthyroidism, BPH, CVD, autonomic neuropathy, HTN, partial obstructive uropathy, toxin-mediated diarrhea, hepatic/renal impairment, tachyarrhythmia, Down syndrome, brain damage in children, salivary secretion disorder, hiatal hernia, reflex esophagitis

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: trace amounts enter breast milk; use with caution (AAP Committee states "compatible with nursing")

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Antimuscarinic; inhibits action of acetylcholine at parasympathetic sites in smooth muscle, CNS, and secretory glands. Increases cardiac output and dries secretions

            Pharmacokinetics

            Metabolism: Liver

            Half-Life: 2.5 hr

            Excretion: Urine

            Absorption: 90%

            Onset: <1 hr

            Duration: 4 hr

            Peak plasma time: 1 hr

            Peak effect: 2 hr

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            • Compare formulary status to other drugs in the same class.
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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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