Dosing & Uses
Dosage Forms & Strengths
1-2 gtts solution, cycloplegia 1 hour before refraction & mydriasis 7-14 days
1-2 gtt up to four times daily
Ocular: Flush eyes with water
Ingestion: Emesis, lavage
Dosage Forms & Strengths
1 gtts (0.5%) qDay to three times daily
Frequency Not Defined
Hyperreactive response in Down's syndrome children (atropine)
Increased intraocular pressure
Narrow angle glaucoma, adhesions between iris and lens
Although, mydriatic/cycloplegic effects last for up to 2 wk in an uninflammed eye, an inflammed eye may require 2-4 times DAILY dosing to see an effective pharmacologic effect
Nor for injection; topical use only
While pupils are dialated patients are advised not to engage in hazardous activities like driving
Administration to infants requires caution; may produce systemic symptoms (discontinue medication if this occurs
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Trace amounts enter breast milk; use with caution (AAP Committee states "compatible with nursing")
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Blocks the action of acetylcholine resulting in relaxation of the cholinergically innervated sphincter muscle of the iris
Cholinergic stimulation of the accommodative ciliary muscle of the lens is also blocked
Anticholinergic effects of atropine sulfate in the eye produce dilation of the pupil (mydriasis) and paralysis of accommodation (cycloplegia)
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