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atropine ophthalmic (Rx)Brand and Other Names:IsoptoAtropine

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ointment

  • 1%

solution

  • 1%
more...

Mydriasis/Cycloplegia

1-2 gtts solution, cycloplegia 1 hour before refraction & mydriasis 7-14 days

Uveitis

1-2 gtt up to four times daily

Overdose Management

Ocular: Flush eyes with water

Ingestion: Emesis, lavage

Dosage Forms & Strengths

ointment

  • 1%

solution

  • 1%
more...

Uveitis (Off-label)

1 gtts (0.5%) qDay to three times daily

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Adverse Effects

Frequency Not Defined

Local irritation

Hyperemia

Edema

Dry eyes

Exudate

Follicular conjunctivitis

Vascular congestion

Dermatitis

Blurred vision

Hyperreactive response in Down's syndrome children (atropine)

Drowsiness

Increased intraocular pressure

Physostigmine

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Warnings

Contraindications

Narrow angle glaucoma, adhesions between iris and lens

Cautions

Although, mydriatic/cycloplegic effects last for up to 2 wk in an uninflammed eye, an inflammed eye may require 2-4 times DAILY dosing to see an effective pharmacologic effect

Nor for injection; topical use only

While pupils are dialated patients are advised not to engage in hazardous activities like driving

Administration to infants requires caution; may produce systemic symptoms (discontinue medication if this occurs

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Trace amounts enter breast milk; use with caution (AAP Committee states "compatible with nursing")

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Absorption: transconjunctivally

Excretion: urine

Mechanism of Action

Blocks the action of acetylcholine resulting in relaxation of the cholinergically innervated sphincter muscle of the iris

Cholinergic stimulation of the accommodative ciliary muscle of the lens is also blocked

Anticholinergic effects of atropine sulfate in the eye produce dilation of the pupil (mydriasis) and paralysis of accommodation (cycloplegia)

Pharmacokinetics

Absorption: Transconjunctival

Excretion: Urine

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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