Kava (Herbs/Suppl)

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Brand and Other Names:ava pepper, awa, more...intoxicating pepper, kao, kawa, kew, piper methysticum, sakau, tonga, yagona

Suggested Dosing

Anxiety disorders

70% standardized extract: 100 mg PO TID

Kava-lactones: 60-120 mg/day PO

Root tea: 1 cup PO qD-TID; 2-4 g root/150 ml water

Benzodiazepine withdrawal, prevention

70% stdzd extract

  • Initial: 50 mg PO qD, THEN
  • Titrate up over 1 week while tapering benzodiazepine over 2 weeks
  • No more than 300 mg/day titrated over 1 week

Insomnia

Kava-lactones: 180-210 mg PO qHS

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Suggested Uses

Anxiety disorders, benzodiazepine withdrawal, common cold/URIs, depression, epilepsy, headaches/migraines, insomnia, musculoskeletal pain, psychosis, stress

Efficacy

Likely effective for anxiety, insomnia (short-term)

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Interactions

Interaction Checker

and Kava

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Allergic skin reactions

            Dizziness

            Drowsiness

            Enlarged pupils

            Gastrointestinal upset

            Headache

            Hepatitis (acute)

            Hepatotoxicity

            Liver failure

            Motor reflex impairment

            Oculomotor equilibrium disturbances

            Parkinsonism

            Visual accommodation disturbances

            Body weight decreases (chronic use)

            Facial puffiness (chronic use)

            Hematuria (chronic use)

            Kava dermopathy (chronic use)

            Lymphocytopenia (chronic use)

            Movement disorders (chronic use)

            Protein levels decrease (chronic use)

            Pulmonary hypertension (chronic use)

            Rash (chronic use)

            Red blood cell volume increases (chronic use)

            Thrombocytopenia (chronic use)

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            Warnings

            Contraindications

            Hepatitis, acute or hx

            Cautions

            Depression

            Risk of liver failure: banned in many countries (UK, Sweden, Netherlands etc)

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            Pregnancy & Lactation

            Pregnancy Category: unsafe

            Lactation: unsafe

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Kavalactones act on limbic system

            No evidence of binding to GABA or opioid receptors

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