Wheat Germ Extract (Herbs/Suppl)

Brand and Other Names:avemar
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Suggested Dosing

9 g PO qDay

>90 kg: 9 g PO BID

Administration

Mix powder in 150 mL water or other liquid not containing vitamin C

Take 1 hour before meals

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Suggested Uses

Certain cancers, esp colorectal

Efficacy

Small clinical trials showed significant improvement in progression-free & overall survival (Br J Cancer 89, 465-469: 2003) & absence of metastases (Hepato-Gastroenterology 47, 393-395:2000) in colorectal cancer patients compared to control groups

Other studies indicate survival benefit in melanoma & quality-of-life improvement in breast cancer

Approved in Hungary as a medical nutriment

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Interactions

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            Adverse Effects

            Soft stools, nausea, diarrhea

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            Warnings

            Contraindications

            Pregnancy, lactation

            Malabsorption syndrome, GI ulcers, celiac sprue, gluten sensitivity

            Pattients undergoing transplants

            Inherited fructose intolerance

            Hypersensitivity

            Cautions

            Give only when patient has been able to take food orally without complications for at least 4 days

            Give other medicinal products or supplements at least 2 hours apart (esp vitamin C)

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            Pregnancy & Lactation

            Pregnancy Category: avoid

            Lactation: avoid

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Induces apoptosis in cancer cells; also immunostimulatory & hematopoietic effects

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