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caprylidene (Rx)Brand and Other Names:Axona, caprylic triglyceride

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral powder

  • 40g/packet (each 40g packet contains 20g of medium chain triglycerides [MCTs])
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Alzheimer Disease

Indicated for clinical dietary management of metabolic processes associated with mild-to-moderate Alzheimer disease

40 g (1 packet of powder, containing 20 g MCTs) PO qDay

Administration

Mix contents of each 40 g packet with 4-8 oz of water; shake until fully blended and drink immediately

Reconstituted product may be refrigerated for up to 24 hr, then reblended and thoroughly mixed before consumption

If GI adverse effects occur, may temporarily give simethicone, antacids, or antidiarrheal agents

For persistent GI symptoms, decrease dose to one-half packet qDay until adverse effects resolve, then resume taking full packet

Additional Supplement Ingredients

Also contains potassium caseinate (milk-derived protein), maltodextrin, whey protein (milk-derived), sugar, sunflower oil, dimagnesium phosphate, tricalcium phosphate, dipotassium phosphate, soy lecithin, distilled monoglyceride, sodium ascorbate (vitamin C), silicon dioxide, natural vanilla bean extract, vitamin E acetate, vitamin A palmitate, zinc sulfate, pyridoxine HCl (vitamin B6), folic acid, and chromium chloride

Not indicated

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Adverse Effects

>10%

Diarrhea

Flatulence

1-10%

Dizziness

Headache

Dyspepsia

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Warnings

Contraindications

Allergy to milk or soy (contains caseinate, whey, and lecithin)

Cautions

Hypersensitivity to palm or coconut oil

Patients at risk for ketoacidosis (eg, alcoholics, poorly controlled diabetics)

History of GI inflammatory conditions (eg, IBS, diverticulitis, chronic gastritis, GERD)

May increase triglycerides (periodically monitor serum triglyceride level)

Renal effects: may increase BUN, uric acid, or serum creatinine

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Pregnancy & Lactation

Pregnancy Category: C; not studied in women <50 years old

Lactation: Unknown whether distributed in breast milk, caution advised

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Mechanism of Action

Prescription medical food metabolized into ketone bodies to product hyperketonemia, thus provides an alternate glucose substrate to brain

The brain can use these ketone bodies for energy when its ability to process glucose is impaired

Brain-imaging scans of older adults and those with Alzheimer disease reveal a dramatically decreased uptake of glucose

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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