Brand and Other Names:balsam apple, balsam pear, more...bitter apple, bitter cucumber, bitter gourd, karela, lakwa, margose, momordica charantia, wild cucumber
- Classes: Metabolic & Endocrine, Herbals
50-100 mL qD OR
900 mg of fruit TID
Diabetes, psoriasis, GI upset, anti-microbial, HIV, cancer, fertility, skin diseases
Preliminary research shows that it decreases blood glucose & HgbA1C in type 2 diabetes
Serious - Use Alternative
Significant - Monitor Closely
Concomitant hypoglycemic medications
Pregnancy & Lactation
Pregnancy Category: X
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Mechanism of Action
Polypeptide P: insulin-like properties (onset 30-60min; peak 4 hours)
Also has anticancer proteins