Sea Cucumber (Herbs/Suppl)

Brand and Other Names:beche-de-mer, haishen, more...holothurian, trepang
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Suggested Dosing

See Mfr's instructions

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Suggested Uses

Cancer, arthritis, impotence, urinary frequency

Efficacy

In vitro studies show potential; few clinical trials to verify medicinal claims but pharmaceutical companies have shown interest; used in traditional Asian medicine

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Adverse Effects

Generally well-tolerated

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Warnings

Cautions

Seafood allergy

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Pregnancy & Lactation

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

12-methyltetradecanoic acid, a branched-chain fatty acid isolated from sea cucumber, is thought to inhibit prostate cancer cell proliferation by increasing caspase-3 activity

Philinopside A, a saponin derived from sea cucumber, is antiangiogenic & antineoplastic in vitro presumably by inhibiting tyrosine kinase

Rich in muciopolysaccharides, esp chondroitin sulfate, useful for arthritis

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