Red Clover (Herbs/Suppl)

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Brand and Other Names:beebread, cow clover, more...meadow clover, purple clover, trefle des pres, trefoil, trifolium pratense, wild clover

Suggested Dosing

Typical Dosing Guideline

Standardized commercially prepared isoflavins

40-80 mg/day

Flower Tops

4 g PO TID

Tea

1 cup PO TID; 4 g flower tops/150 mL water

Liquid Extract

1.5-3 mL PO TID; 1:1 in 25% alcohol

Tincture

1-2 mL PO TID; 1:10 in 45% alcohol

Topical

Dosage varies

Hot Flash

Isoflavone extract: 40-160 mg/day PO

Cyclic Mastalgia

Isoflavones: 40-80 mg/day

Osteoporosis

Specific extract (Promensil): 40 mg/day

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Suggested Uses

Oral

Menopausal symptoms and hot flashes, mastalgia, PMS, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, & STD's

Topical

Cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema

Efficacy

Hypercholesterolemia

  • Does not significantly reduce total or LDL cholesterol, OR increase HDL in women 49-65. More studies are needed

Menopausal symptoms

  • Does not seem to reduce menopausal symptoms

BPH

  • May decrease nocturnal urinary frequency, international prostate symptom scores, and improve the quality of life
  • Does not affect urine flow rate, PSA values, or prostate size

Breast Cancer (prevention)

  • May not significantly affect breast cancer risk

Endometrial cancer

  • It is not known if has any effect on risk. More studies are needed

Mastalgia

  • Preliminary evidence suggests reduction in breast pain & tenderness in 45% of patients

Osteoporosis

  • More studies are needed. 40 mg isoflavones qDay did not seem to increase BMD
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Interactions

Interaction Checker

and Red Clover

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Estrogen-like effects, rash

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            Warnings

            Contraindications

            Cancer (breast, ovarian, uterine), endometriosis, hormone sensitive conditions, uterine fibroids

            Cautions

            Coagulation disorders, concurrent CYP3A4 substrates

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            Pregnancy & Lactation

            Pregnancy Category: avoid use

            Lactation: avoid use

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Metabolism: N/A

            Excretion: N/A

            Mechanism of Action

            Antispasmodic, expectorant constituents

            Isoflavones (e.g., daidzein, genistein) are phytoestrogens: weak estrogenic/antiestrogenic properties

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