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belladonna and opium (Rx)Brand and Other Names:B and O Suppositories

 
 
 

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

suppository: Schedule II

  • 16.2mg/30mg
  • 16.2mg/60mg
more...

Ureteral Spasm Pain

Indicated for severe pain associated with ureteral spasm unresponsive to nonnarcotic analgesics or to space intervals between opiate injections

1 suppository PR qDay or q12hr

Not to exceed 4 doses/day

Dosage Forms & Strengths

suppository: Schedule II

  • 16.2mg/30mg
  • 16.2mg/60mg
more...

Ureteral Spasm Pain

<12 years

  • Not recommended

>12 years

  • Indicated for severe pain associated with ureteral spasm unresponsive to nonnarcotic analgesics or to space intervals between opiate injections
  • 1 suppository PR qDay or q12hr
  • Not to exceed 4 doses/day

Ureteral Spasm Pain

Indicated for severe pain associated with ureteral spasm unresponsive to nonnarcotic analgesics or to space intervals between opiate injections

1 suppository PR qDay or q12hr

Not to exceed 4 doses/day

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Interactions

Interaction Checker

belladonna and opium and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Pruritus

            Urticaria

            Nausea

            Vomiting

            Photophobia

            Anticholinergic

            • Dizziness
            • Sedation
            • Urticaria
            • Constipation
            • Dry mouth
            • Blurred vision
            • Urinary retention
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            Warnings

            Contraindications

            Hypersensitivity

            Respiratory disease/depression, pseudomembranous colitis, severe hepatic dz, convulsive disorders, GI obstruction, myasthenia gravis, angle-closure glaucoma, obstructive uropathy, paralytic ileus, intestinal atony of elderly or debilitated pt, unstable cardiovascular status in acute hemorrhage, severe ulcerative colitis, toxic megacolon, tachycardia secondary to cardiac insufficiency or thyrotoxicosis

            Cautions

            Asthma, BPH, hepatic dz, history of opioid dependence, reflux esophagitis, hiatal hernia, mitral stenosis, pts who are concurrently on CNS depressant

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Opium: analgesic, antispasmodic, antimuscarinic; because of its morphine content, inhibits GI motility and propulsion, diminishes digestive secretion

            Belladonna: anticholinergic alkaloids; competitively inhibit Ach actions at muscarinic receptors

            Pharmacokinetics

            Onset: Opium: 30 min, Belladonna: 1-2 hr

            Metabolism: opium: extensively in liver, undergoes conjugation with glucuronic acid; belladonna: no data

            Metabolites: opium: morphine-3-glucuronide, morphine-3-6-diglucuronide; belladonna: no data

            Excretion: opium: mainly by kidney, little amount in bile; belladonna: urine

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            Images

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            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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