diphenhydramine/pseudoephedrine (Discontinued)

Brand and Other Names:Benadryl Children's Allergy and Cold Fastmelt, Benadryl D Allergy and Sinus Fastmelt, more...Benadryl D Children's Allergy and Sinus
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

diphenhydramine/pseudoephedrine

liquid

  • (12.5mg/30mg)/5mL

quick dissolving tablet

  • 19mg/30mg
more...

Relief of Symptoms of Upper Respiratory Mucosal Congestion

Based on pseudoephedrine component: 60 mg PO q4-6hr; not to exceed 240 mg/day

Dosage Forms & Strengths

diphenhydramine/pseudoephedrine

liquid

  • (12.5mg/30mg)/5mL

quick dissolving tablet

  • 19mg/30mg
more...

Relief of Symptoms of Upper Respiratory Mucosal Congestion

Ask a pediatrician

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Interactions

Interaction Checker

and diphenhydramine/pseudoephedrine

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            Adverse Effects

            Frequency Not Defined

            Arrhythmia

            Hypotension

            Palpitations

            Tachycardia

            Convulsion

            Dizziness

            Drowsiness

            Excitability

            Sedation

            Tremor

            Weakness

            Increased appetite

            Xerostomia

            Urinary retention

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            Warnings

            Contraindications

            Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, and bladder-neck obstruction

            Diphenhydramine may cause significant confusional symptoms; not for administration to premature or full-term neonates

            Cautions

            Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine

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            Pregnancy & Lactation

            Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Diphenhydramine competitively blocks histamine from binding to H1 receptors. Has significant antimuscarinic activity and penetrates CNS, which causes pronounced tendency to induce sedation

            Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction

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            Images

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