Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

benzoyl peroxide (Rx, OTC)Brand and Other Names:Benzac AC Gel, Desquam-X, more...Benzac AC Wash, Benzac Acne Eliminating Cleanser, BenzEFoam, BPO Creamy Wash Complete Pack, BPO Foaming Cloth, BPO Gel, Clean and Clear Advantage 3-in-1 Exfoliating Cleanser, Clean and Clear Continuous Control Acne Cleanser, Clean and Clear Gel, Clearasil Vanishing Acne Treatment Cream, Lavoclen-4 Creamy Wash, Lavoclen-8 Creamy Wash, NeoBenz Micro, NeoBenz Micro SD, NeoBenz Micro Wash, Neutrogena Benzoyl Peroxide Lotion, Neutrogena Clear Pore Acne Treatment, Neutrogena On-The-Spot Acne Treatment, Neutrogena Clear Pore Daily Scrub, Pacnex MX, PanOxyl Acne Cleansing Bar, PanOxyl Acne Creamy Wash, PanOxyl Acne Foaming Wash, Proactiv, Proactiv Advanced Blemish Treatment, Proactiv Renewing Cleanser, Proactiv Repairing, Riax, Zapzyt Acne Treatment Gel

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

topical gel

  • 2.5% (Proactive Repairing)
  • 4% (BPO Gel)
  • 5% (Benzac AC Gel, Clean and Clear Gel)
  • 8% (BPO Gel)
  • 10% (Benzac AC Gel, Zapzyt Acne Treatment Gel)

topical lotion

  • 2.5% (Proactive Repairing)
  • 3.5% (Neutrogena Benzoyl Peroxide Lotion)
  • 7% (Proactiv)

bar

  • 10% (PanOxyl Acne Cleansing Bar)

topical cream

  • 2.5% (Neutrogena On-The-Spot Acne Treatment, Proactiv)
  • 5.5% (NeoBenz Micro, NeoBenz Micro SD)
  • 6% (Proactiv Advanced Blemish Treatment)
  • 7% (Proactiv)
  • 10% (Clearasil Vanishing Acne Treatment Cream, Neutrogena Clear Pore Acne Treatment)

topical foam

  • 5.3% (BenzEFoam)
  • 5.5% (Riax)
  • 9.5% (Riax)

topical wash

  • 2.5% (Proactiv Renewing Cleanser)
  • 3% (BPO Foaming Cloth)
  • 3.7% (Neutrogena Clear Pore Daily Scrub)
  • 4% (PanOxyl Acne Creamy Wash, Lavoclen-4 Cream Wash)
  • 4.25% (Pacnex MX)
  • 5% (Benzac AC Wash, Clean and Clear Advantage 3-in-1 Exfoliating Cleanser)
  • 6% (BPO Foaming Cloth)
  • 7% (NeoBenz Micro Wash)
  • 8% (Lavoclen-8 Creamy Wash)
  • 9% (BPO Foaming Cloth)
  • 10% (PanOxyl Acne Foaming Wash, Clean and Clear Continuous Control Acne Cleanser)

topical gel cleanser

  • 2.6% (Benzac Acne Eliminating Cleanser)
more...

Acne Vulgaris

Topical formulations: Apply sparingly to affected areas qDay after thoroughly washing skin; may gradually increase to BID/TID if needed

Topical cleansers: Wash qDay or BID; decrease frequency or product concentration if excessive dryness occurs

Dosage Forms & Strengths

topical gel

  • 2.5% (Proactive Repairing)
  • 4% (BPO Gel)
  • 5% (Benzac AC Gel, Clean and Clear Gel)
  • 8% (BPO Gel)
  • 10% (Benzac AC Gel, Zapzyt Acne Treatment Gel)

topical lotion

  • 2.5% (Proactive Repairing)
  • 3.5% (Neutrogena Benzoyl Peroxide Lotion)
  • 7% (Proactiv)

bar

  • 10% (PanOxyl Acne Cleansing Bar)

topical cream

  • 2.5% (Neutrogena On-The-Spot Acne Treatment, Proactiv)
  • 5.5% (NeoBenz Micro, NeoBenz Micro SD)
  • 6% (Proactiv Advanced Blemish Treatment)
  • 7% (Proactiv)
  • 10% (Clearasil Vanishing Acne Treatment Cream, Neutrogena Clear Pore Acne Treatment)

topical foam

  • 5.3% (BenzEFoam)

topical wash

  • 2.5% (Proactiv Renewing Cleanser)
  • 3% (BPO Foaming Cloth)
  • 3.7% (Neutrogena Clear Pore Daily Scrub)
  • 4% (PanOxyl Acne Creamy Wash, Lavoclen-4 Cream Wash)
  • 4.25% (Pacnex MX)
  • 5% (Benzac AC Wash, Clean and Clear Advantage 3-in-1 Exfoliating Cleanser)
  • 6% (BPO Foaming Cloth)
  • 7% (NeoBenz Micro Wash)
  • 8% (Lavoclen-8 Creamy Wash)
  • 9% (BPO Foaming Cloth)
  • 10% (PanOxyl Acne Foaming Wash, Clean and Clear Continuous Control Acne Cleanser)

topical gel cleanser

  • 2.6% (Benzac Acne Eliminating Cleanser)
more...

Acne Vulgaris

Adolescents

Topical formulations: Apply sparingly to affected areas qDay after thoroughly washing skin; may gradually increase to BID/TID if needed

Topical cleansers: Wash qDay or BID; decrease frequency or product concentration if excessive dryness occurs

Next

Interactions

Interaction Checker

benzoyl peroxide and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Contact dermatitis

            Erythema

            Peeling

            Skin dryness

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            For external use only; avoid contact with the eyes, lips, and mouth

            Skin irritation may occur, characterized by redness, burning, itching, peeling, or possibly swelling; decrease frequency of use or use lower concentration product

            Stop use if irritation becomes severe

            Coadministration with other topical acne medications may increase skin irritation and dryness

            Avoid excessive sun exposure and use sunscreen

            Avoid contact with hair and dyed fabrics (eg, pillow cases, towels), which may be bleached by this product

            Serious allergic reactions

            • Rare but serious and potentially life-threatening allergic reactions or severe irritation reported
            • Instruct patients to stop using their topical acne product and seek emergency medical attention immediately if they experience hypersensitivity reactions (eg, throat tightness, difficulty breathing, feeling fain, or swelling of the eyes, face, lips, or tongue)
            • Also instruct patients to stop using the product if they develop hives or itching
            • These serious hypersensitivity reactions differ from the local skin irritation that may occur at the product application site (eg, redness, burning, dryness, itching, peeling, or slight swelling)
            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: excretion in milk unknown; use with caution

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Elicits action by releasing active oxygen; effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones; also elicits a keratolytic and desquamative effect which may also contribute to its efficacy

            Pharmacokinetics

            Benzoyl peroxide absorbed by the skin where it is converted to benzoic acid

            Previous
            Next

            Administration

            Instructions

            Before using a topical acne product for the first time, patients should apply a small amount to 1 or 2 small affected areas of the skin for 3 days, if no discomfort/allergy occurs, then the product can be used according to the directions

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.