Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

clindamycin/benzoyl peroxide (Rx)Brand and Other Names:BenzaClin, Acanya, more...Duac, Onexton

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

clindamycin/benzoyl peroxide

topical gel

  • 1%/5% (BenzaClin)
  • 1.2%/2.5% (Acanya)
  • 1.2%/3.75% (Onexton)
  • 1.2%/5% (Duac)
more...

Acne Vulgaris

BenzaClin: Apply topically q12hr to affected areas after skin is thoroughly washed and patted dry

DUAC: Apply once daily in the evening to affected areas after the skin is thoroughly washed and patted dry

Acanya, Onexton: Apply pea-sized amount qDay to affected areas after skin is thoroughly washed and patted dry

Limitation of use

  • DUAC Gel has not been demonstrated to have any additional benefit when compared with benzoyl peroxide alone in the same vehicle when used for the treatment of non-inflammatory acne

Dosage Forms & Strengths

clindamycin/ benzoyl peroxide

topical gel

  • 1%/5% (BenzaClin)
  • 1.2%/2.5% (Acanya)
  • 1.2%/3.75% (Onexton)
  • 1.2%/5% (Duac)
more...

Acne Vulgaris

<12 years: Safety and efficacy not established

≥12 years

  • BenzaClin: Apply topically qHS to affected areas after skin is thoroughly washed and patted dry
  • DUAC: Apply once daily in the evening to affected areas after the skin is thoroughly washed and patted dry
  • Acanya, Onexton: Apply pea-sized amount qDay to affected areas after skin is thoroughly washed and patted dry
  • Limitation of use
    • DUAC Gel has not been demonstrated to have any additional benefit when compared with benzoyl peroxide alone in the same vehicle when used for the treatment of non-inflammatory acne
Next

Interactions

Interaction Checker

clindamycin/benzoyl peroxide and

No Results

     
     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            Sort by :  
             activity indicator 
            Previous
            Next

            Adverse Effects

            Frequency Not Defined

            Application site pain

            Application site exfoliation

            Application site irritation

            Erythema

            Burning

            Pruritus

            Sunburn

            Scaling

            Dryness

            Diarrhea

            Colitis

            Peeling

            Postmarketing reports

            Anaphylaxis, as well as allergic reactions leading to hospitalization

            Urticaria, application site reactions, including discoloration

            Previous
            Next

            Warnings

            Contraindications

            Hypersensitivity to clindamycin, benozyl peroxide, lincomycin or any of the drug components

            History of regional enteritis, ulcerative colitis or antibiotic-associated colitis (including pseudomembranous colitis)

            Cautions

            Systemic absorption of clindamycin has been demonstrated following topical use; discontinue immediately if significant diarrhea occurs and consider large bowel endoscopy

            May cause irritation, especially when used with concomitant topical acne therapy including peeling, desquamating, or abrasive agents

            Should be used with caution in atopic individuals

            For external use only; avoid contact with eyes and mucous membranes

            Minimize sun expsoure following application

            May have bleaching effects on hair or colored fabric

            Bacterial of fungal superinfection may result from prolonged use

            Concomitant topical acne therapy may result in cumulative irritation, especially with the use of peeling, desquamating, or abrasive agents; if this occurs, discontinue and seek medical advice

            Do not use clindamycin and erythromycin containing products together

            Previous
            Next

            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Excretion in milk unknown/not recommended

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

            more...
            Previous
            Next

            Pharmacology

            Mechanism of Action

            Clindamycin: Antibacterial agent that binds to the 50S ribosomal subunits of susceptible bacteria and prevents elongation of peptide chains by interfering with peptidyl transfer, thereby suppressing protein synthesis; reduces surface fatty acids on skin; exact mechanism of action in treating acne unknown

            Benzoyl peroxide: Elicits action by releasing active oxygen; effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones; also elicits a keratolytic and desquamative effect which may also contribute to its efficacy

            Previous
            Next

            Images

            Previous
            Next

            Formulary

            FormularyPatient Discounts

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
            Add or Remove Plans
            Plans for
            Select State:
            Non-Medicare PlansMedicare Plans

            Select a box to add or remove a plan.

            Select a class to view formulary status for similar drugs

            Additional Offers
            Email to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Email Forms to Patient

            From:

            To:

            The recipient will receive more details and instructions to access this offer.

            By clicking send, you acknowledge that you have permission to email the recipient with this information.

            Previous
             
             
             
            All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.