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erythromycin topical/benzoyl peroxide (Rx)Brand and Other Names:Benzamycin, Benzamycin Pak

 
 
 

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

erythromycin topical/benzoyl peroxide

topical gel

  • 3%/5%
more...

Acne Vulgaris

Apply topically BID (morning and evening) to affected areas after skin is thoroughly washed and patted dry

Administration

Benzamycin Pak: Requires thorough mixing by the patient immediately prior to each use; may store at room temperature

Benzamycin: After reconstitution; store refrigerated between 2-8°C (36-46°F); do not freeze

Dosage Forms & Strengths

erythromycin topical/benzoyl peroxide

topical gel

  • 3%/5%
more...

Acne Vulgaris

<12 years: Safety and efficacy not established

≥12 years: Apply topically BID (morning and evening) to affected areas after skin is thoroughly washed and patted dry

Administration

Benzamycin Pak: Requires thorough mixing by the patient immediately prior to each use; may store at room temperature

Benzamycin: After reconstitution; store refrigerated between 2-8°C (36-46°F); do not freeze

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Adverse Effects

1-10%

Dry skin (5-7.6%)

Application site reaction (stinging, erythema, burning) (0.8-2.5%)

Blepharitis (1.7%)

Pruritus (1.7-2.5%)

Photosensitivity (1.3%)

<1%

Skin peeling (<0.5%)

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Warnings

Contraindications

Hypersensitivity

Cautions

For external use only; avoid contact with eyes and other mucous membranes

Concomitant topical acne therapy may result in cumulative irritation, especially with the use of peeling, desquamating, or abrasive agents; if this occurs, discontinue and seek medical advice

Although limited systemic absorption occurs with topical erythromycin, antibiotics may be associated with the overgrowth of nonsusceptible organisms; if this occurs, discontinue use and contact physician

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: excretion in milk unknown; use with caution

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

more...
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Pharmacology

Mechanism of Action

The exact mechanism by which erythromycin and benzoyl peroxide reduce lesions of acne vulgaris is not fully known

Erythromycin: Inhibits protein synthesis in susceptible organisms by reversibly binding to 50 S ribosomal subunits, thereby inhibiting translocation of aminoacyl transfer-RNA and inhibiting polypeptide synthesis

Benzoyl peroxide: Elicits action by releasing active oxygen; effective in vitro against Propionibacterium acnes, an anaerobe found in sebaceous follicles and comedones; also elicits a keratolytic and desquamative effect which may also contribute to its efficacy

Pharmacokinetics

Benzoyl peroxide absorbed by the skin where it is converted to benzoic acid

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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