propylhexedrine (OTC)

Brand and Other Names:Benzedrex
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

intranasal inhaler

  • 250mg/actuation
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Nasal Congestion

1-2 inhalations per nostril q2hr PRN; not to exceed 3 days

Dosage Forms & Strengths

intranasal inhaler

  • 250mg/actuation
more...

Nasal Congestion

<6 years: Not recommended

≥6 years: 1-2 inhalations per nostril q2hr PRN; not to exceed 3 days

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Interactions

Interaction Checker

and propylhexedrine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Systemic side effects more common in patients with heart disease, especially if overused

            Frequency Not Defined

            Anxiety

            Restlessness

            Tremor

            Sweating

            Stinging

            Dryness

            Rebound congestion

            Burning

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            Warnings

            Contraindications

            Hypersensitivity to drug or components

            Within 14 days of MAO inhibitor therapy

            Cautions

            WARNING: may be extracted & injected IV as amphetamine substitute by abusers: Potential for cardiomyopathy, dyspnea, death

            Caution in cardiac disease (increase BP, HR, palpitations)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: not known if excreted in breast milk

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Cycloalkylamine; alpha adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion

            Pharmacokinetics

            Absorption: Minimal systemic

            Onset: 30 sec-5 min

            Duration: 30 min-2 hr

            Metabolism: Liver

            Metabolites: Norpropylhexedrine, cyclohexylacetoxine, & 4-hydroxypropylhexedrineExcretion: urine

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            Images

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