Goldenseal (Herbs/Suppl)

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Brand and Other Names:berberine, eye balm, more...eye root, goldenroot, ground raspberry, Hydrastis canadensis, Indian plant, jaundice root, orange root, yellow root

Suggested Dosing

Dried Root/Rhizome/Tea

0.5-1 g PO TID

Liquid Extract

0.3-1.0 ml PO TID; 1:1, 60% ethanol

Tincture

2-4 ml PO TID; 1:10, 60% ethanol

Mouthwash, Topical

Rinse TID-QID; with 6 g dried herb/150 ml water

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Suggested Uses

Common cold, conjunctivitis, diarrhea, dysmenorrhea/menorrhagia, flatulence, gastritis/colitis, mouth/gum sores, respiratory infections, ringworm, urinary tract infections, urine drug tests

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Adverse Effects

Frequency Not Defined

Bradycardia (Overdose: OD)

Cardiac damage (OD)

Constipation

Death (OD)

Delirium

Depression (OD)

Digestive disorders

Dyspnea (OD)

Excitability

Hallucinations

Hypotension (OD)

Kernicterus (peds)

Mucosal irritation

Nausea/vomiting (OD)

Nervousness (OD)

Paralysis (OD)

Respiratory failure (OD)

Seizures (OD)

Spasms (OD)

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Warnings

Contraindications

Breast-feeding, hyperbilirubinemia, infectious GI conditions, inflammatory GI conditions, newborn/infant, pregnancy

Cautions

Cardiovascular disorders, concurrent antihypertensives, concurrent CYP 3A4 substrates, concurrent sedative agents, hypertension

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Pregnancy & Lactation

Pregnancy Category: X

Lactation: unsafe

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

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Pharmacology

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Active constituent, berberine, has broad-spectrum antimicrobial & antiinfective activity

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